Is Lercanidipine Hydrochloride Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Lercanidipine Hydrochloride? Is Lercanidipine Hydrochloride safe for nursing mother and child? Does Lercanidipine Hydrochloride extracts into breast milk? Does Lercanidipine Hydrochloride has any long term or short term side effects on infants? Can Lercanidipine Hydrochloride influence milk supply or can Lercanidipine Hydrochloride decrease milk supply in lactating mothers?
Lercanidipine Hydrochloride lactation summary
- DrLact safety Score for Lercanidipine Hydrochloride is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Lercanidipine Hydrochloride may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Lercanidipine Hydrochloride may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Lercanidipine Hydrochloride low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Lercanidipine Hydrochloride We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Lercanidipine Hydrochloride usage in lactation
At latest update no published data were found on excretion into breast milk. Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.Its high plasma protein binding capacity makes it unlikely any passage to the milk, however, its high lipid solubility facilitates excretion into it. Although it has a low oral bioavailability, it may increase to four times if administered with a fatty meal, which would increase the oral absorption in the infant. Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.
Alternate Drugs for Anti-hypertensive Calcium channel-Blocker. ATC C08
Amlodipine(Low Risk)
Diltiazem(Safe)
Felodipine(Low Risk)
Isradipine(Low Risk)
Nifedipine(Safe)
Nimodipine(Safe)
Nisoldipine(Low Risk)
Nitrendipine(Safe)
Verapamil(Safe)
Nicardipine(Safe)
Amlodipine Besylate(Low Risk)
Verapamil Hydrochloride(Safe)
Bepridil Hydrochloride(Unsafe)
Diltiazem Hydrochloride(Safe)
Manidipine Hydrochloride(Low Risk)