Is CCRIS 5502 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use CCRIS 5502? Is CCRIS 5502 safe for nursing mother and child? Does CCRIS 5502 extracts into breast milk? Does CCRIS 5502 has any long term or short term side effects on infants? Can CCRIS 5502 influence milk supply or can CCRIS 5502 decrease milk supply in lactating mothers?

Biliary salt that appears in low amount in the serum because it is absorbed to the portal circulation and completely excreted into biliary duct. Excreted into breast milk in non-significant amount with no side-effects being observed among infants of treated mothers. Medication that has been used for treatment of newborns and older infants.

Because of the low levels of CCRIS 5502 (ursodeoxycholic acid) in breastmilk, amounts ingested by the infant are small and are not expected to cause any adverse effects in breastfed infants. No special precautions are required.

One breastfed (extent not stated) infant developed normally over the first 6 months of life during maternal CCRIS 5502 therapy of 750 to 1000 mg daily.[1] Seven women who were taking CCRIS 5502 14 mg/kg daily near term and postpartum. They reported no adverse reactions in their breastfed infants during the early postpartum period.[2] A mother receiving oral CCRIS 5502 250 mg 3 times daily for primary biliary cirrhosis reportedly breastfed her infant normally, although the extent and duration of breastfeeding was not stated.[4] A woman with primary biliary cirrhosis developed severe pruritus and elevated serum bile acids 3 weeks postpartum. CCRIS 5502 was started at a dose of 500 mg (7.5 mg/kg) daily, increasing to 1500 mg (25 mg/kg) daily over the next 8 weeks. Psychomotor development of her breastfed (extent not stated) infant was normal, and no apparent side effects were observed in the infant.[3] A woman was breastfeeding her 8-day-old preterm infant 10 times daily for about 15 minutes each time. The infant was born by cesarean section at 34 weeks of gestation with a weight of 3600 grams,. She was diagnosed with cholestasis, type 1 diabetes, and hypothyroidism. She was treated with CCRIS 5502 500 mg daily, insulin levemir and aspart, and levothyroxine. She was also taking cefuroxime, flurbiprofen, a combination of acetaminophen, propyphenazone, and caffeine. The mother took the CCRIS 5502 for a total of 12 days, cefuroxime and the analgesic combination for 10 days and flurbiprofen for 15 days. No adverse effects were noticed during the period of CCRIS 5502 treatment.[5]