Question

I am a breastfeeding mother and i want to know if it is safe to use 4-(Dipropylsulfamoyl)benzoic acid? Is 4-(Dipropylsulfamoyl)benzoic acid safe for nursing mother and child? Does 4-(Dipropylsulfamoyl)benzoic acid extracts into breast milk? Does 4-(Dipropylsulfamoyl)benzoic acid has any long term or short term side effects on infants? Can 4-(Dipropylsulfamoyl)benzoic acid influence milk supply or can 4-(Dipropylsulfamoyl)benzoic acid decrease milk supply in lactating mothers?

4-(Dipropylsulfamoyl)benzoic acid lactation summary

4-(Dipropylsulfamoyl)benzoic acid is safe in breastfeeding
  • DrLact safety Score for 4-(Dipropylsulfamoyl)benzoic acid is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of 4-(Dipropylsulfamoyl)benzoic acid is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that 4-(Dipropylsulfamoyl)benzoic acid does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of 4-(Dipropylsulfamoyl)benzoic acid safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 4-(Dipropylsulfamoyl)benzoic acid usage in lactation

It increases renal excretion of Uric acid and decreases elimination of many drug by the kidneys, among them beta-lactam antibiotics, with augmented plasma levels and effectiveness. Excretion into breast milk is clinically non-significant, with no problems observed among breastfed infants from treated mothers that could be attributed to 4-(Dipropylsulfamoyl)benzoic acid (reportedly, one case of self-limited diarrhea occurred in a child whose mother was taking a Cephalosporin together with 4-(Dipropylsulfamoyl)benzoic acid).

Answer by DrLact: About 4-(Dipropylsulfamoyl)benzoic acid usage in lactation

Limited information indicates that maternal doses of 4-(Dipropylsulfamoyl)benzoic acid up to 2 grams daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. In animal studies, 4-(Dipropylsulfamoyl)benzoic acid increased the breastmilk excretion of cimetidine, possible via an interaction with an active transport mechanism in the breast.[1] The implications of enhanced excretion of drugs given with 4-(Dipropylsulfamoyl)benzoic acid for nursing mothers and their infants has not been studied; however, only a few drugs are known to undergo active transport into breastmilk.

4-(Dipropylsulfamoyl)benzoic acid Side Effects in Breastfeeding

A woman with mastitis received 3 days of intravenous cephalothin, followed by 16 days of 4-(Dipropylsulfamoyl)benzoic acid 500 mg and cephalexin 500 mg 4 times daily for 16 days. Her infant developed green liquid stools, severe diarrhea, discomfort and crying. The authors judged the effects to be probably related to the cephalothin and cephalexin in milk rather than the 4-(Dipropylsulfamoyl)benzoic acid.[2]
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