Is Probenemid Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Probenemid? Is Probenemid safe for nursing mother and child? Does Probenemid extracts into breast milk? Does Probenemid has any long term or short term side effects on infants? Can Probenemid influence milk supply or can Probenemid decrease milk supply in lactating mothers?

It increases renal excretion of Uric acid and decreases elimination of many drug by the kidneys, among them beta-lactam antibiotics, with augmented plasma levels and effectiveness. Excretion into breast milk is clinically non-significant, with no problems observed among breastfed infants from treated mothers that could be attributed to Probenemid (reportedly, one case of self-limited diarrhea occurred in a child whose mother was taking a Cephalosporin together with Probenemid).

Limited information indicates that maternal doses of Probenemid up to 2 grams daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. In animal studies, Probenemid increased the breastmilk excretion of cimetidine, possible via an interaction with an active transport mechanism in the breast.[1] The implications of enhanced excretion of drugs given with Probenemid for nursing mothers and their infants has not been studied; however, only a few drugs are known to undergo active transport into breastmilk.

A woman with mastitis received 3 days of intravenous cephalothin, followed by 16 days of Probenemid 500 mg and cephalexin 500 mg 4 times daily for 16 days. Her infant developed green liquid stools, severe diarrhea, discomfort and crying. The authors judged the effects to be probably related to the cephalothin and cephalexin in milk rather than the Probenemid.[2]