Is Voriconazole Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Voriconazole? Is Voriconazole safe for nursing mother and child? Does Voriconazole extracts into breast milk? Does Voriconazole has any long term or short term side effects on infants? Can Voriconazole influence milk supply or can Voriconazole decrease milk supply in lactating mothers?
Voriconazole lactation summary
- DrLact safety Score for Voriconazole is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Voriconazole may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Voriconazole may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Voriconazole low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Voriconazole We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Voriconazole usage in lactation
Antifungal drug with similar structure than fluconazole available for systemic, oral and intravenous use, and topically for ophthalmic purposes. A latest update no published data on excretion in breast milk were found. Pharmacokinetic data indicates that it may likely pass into the milk in amounts that could be significant.Authorized use in children as young as 2 years of age. It has been used in 10-months-old infants. Until more published data on this drug regarding breastfeeding is available, safer alternatives of better known drugs, should be preferable, especially during the neonatal period and in case of prematurity. The small dose and poor absorption into plasma of most ophthalmic preparations makes it unlikely the pass of the drug into breast milk in significant amount.
Alternate Drugs for Antimycotics for systemic use
Fluconazole(Safe)
Ketoconazole(Safe)
Amphotericin B(Low Risk)
Terbinafine(Safe)
Itraconazole(Safe)
Caspofungine Acetate(Low Risk)
Flucytosine(Unsafe)
Griseofulvin(Safe)
Anidulafungin(Low Risk)
Oriconazole(Safe)