I am a breastfeeding mother and i want to know if it is safe to use Piperacillin + Tazobactam? Is Piperacillin + Tazobactam safe for nursing mother and child? Does Piperacillin + Tazobactam extracts into breast milk? Does Piperacillin + Tazobactam has any long term or short term side effects on infants? Can Piperacillin + Tazobactam influence milk supply or can Piperacillin + Tazobactam decrease milk supply in lactating mothers?

Piperacillin + Tazobactam lactation summary

Piperacillin + Tazobactam is safe in breastfeeding
  • DrLact safety Score for Piperacillin + Tazobactam is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Piperacillin + Tazobactam is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Piperacillin + Tazobactam does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Piperacillin + Tazobactam safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Piperacillin + Tazobactam usage in lactation

Piperacillin (see specific info) is a ureidopenicillin similar to ticarcillin (see specific info).Tazobactam is added as a beta-lactamase inhibitor with few clinical and pharmacokinetic effects similar to that of piperacillin. It is excreted into breastmilk in a clinically insignificant amount (Baier 1982, Chaplin 1982, Wyeth 2007). Because it lacks of oral bioavailability, seems difficult any pass to the infant’s plasma through the breast milk ingested, except on premature infants and immediate neonatal period, in which there may be an increased intestinal permeability. Authorized use in infants and small infants (Chen 2009). Be aware of the likelihood of false negative cultures of febrile infants whose mothers are on antibiotics, as well as the possibility of gastroenteritis due to imbalanced intestinal flora.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.