I am a breastfeeding mother and i want to know if it is safe to use Penicillin G Procaine? Is Penicillin G Procaine safe for nursing mother and child? Does Penicillin G Procaine extracts into breast milk? Does Penicillin G Procaine has any long term or short term side effects on infants? Can Penicillin G Procaine influence milk supply or can Penicillin G Procaine decrease milk supply in lactating mothers?

Penicillin G Procaine lactation summary

Penicillin G Procaine is safe in breastfeeding
  • DrLact safety Score for Penicillin G Procaine is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Penicillin G Procaine is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Penicillin G Procaine does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Penicillin G Procaine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Penicillin G Procaine usage in lactation

At latest update on excretion into breast milk of Penicillin procaine published information was not found. Mother plasma levels of Penicillin procaine have been shown to be lower than those of Penicillin G. Penicillin G is excreted into breast milk in non-significant amounts without side-effects observed among breastfed infants from treated mothers. Plasma levels in those infants were shown to be low or undetectable. Penicillin is a broad spectrum antibiotic that is commonly used in Pediatrics and Neonatology with very good tolerance even in premature newborns. Be aware of false negative results that may be obtained from infants with bacterial cultures when the mother is on antibiotics. Eleventh WHO's Model List of Essential Drugs 2002: Compatible with breastfeeding.

Answer by DrLact: About Penicillin G Procaine usage in lactation

Limited information indicates that penicillin G produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Penicillin G is acceptable in nursing mothers.

Penicillin G Procaine Side Effects in Breastfeeding

A breastfed 1-month-old infant with congenital syphilis developed a Herxheimer reaction 6 hours after its mother received 2.4 million units of benzathine penicillin G intramuscularly. However, the baby had also received 10 units of penicillin G at about the same time as the mother's injection. The reaction was possibly caused by penicillin in breastmilk.[5]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.