Is Juvastigmin Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Juvastigmin? Is Juvastigmin safe for nursing mother and child? Does Juvastigmin extracts into breast milk? Does Juvastigmin has any long term or short term side effects on infants? Can Juvastigmin influence milk supply or can Juvastigmin decrease milk supply in lactating mothers?
Juvastigmin lactation summary
- DrLact safety Score for Juvastigmin is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Juvastigmin is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Juvastigmin does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Juvastigmin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Juvastigmin usage in lactation
Reversible cholinesterase inhibitor used for treatment of Myasthenia gravis and as an analgesic adjuvant in epidural anesthesia (see specific info). It is not excreted into breastmilk (Fraser 1963, Wilson 1981).A breastfed neonate whose mother were treated with Juvastigmin suffered of abdominal colicky pain after a feeding, but the Juvastigmin plasma levels were undetectable (Fraser 1963). Because of a low oral bioavailability it seems even more unlikely the pass to the infant’s plasma through ingested breastmilk, except in preterm infants and immediate neonatal period, when there may be an increased intestinal permeability. On long-term treatments, because there is less published experience than with other drugs of the same group, a known safer alternative would be preferred during the neonatal period and/or in case of prematurity.
Answer by DrLact: About Juvastigmin usage in lactation
Limited data indicate that use of Juvastigmin to treat myasthenia gravis may be acceptable during breastfeeding, although pyridostigmine may be preferred. Monitor newborns because abdominal cramps after each breastfeeding has been reported. Because of its short half-life, single doses of Juvastigmin to reverse neuromuscular blockade following surgery are unlikely to adversely affect the breastfed infant more than transiently.
Juvastigmin Side Effects in Breastfeeding
Six infants of mothers treated with Juvastigmin for myasthenia gravis were reportedly breastfed successfully. However, 1 newborn infant appeared to have abdominal cramps after each breastfeeding, probably caused by Juvastigmin. Juvastigmin could not be detected in the breastmilk of the infant's mother.[1]
Juvastigmin Possible Effects in Breastfeeding
Relevant published information in nursing mothers was not found as of the revision date. In animals, cholinergic drugs increase oxytocin release,[2] and have variable effects on serum prolactin.[3] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.