Is UNII-3982TWQ96G Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-3982TWQ96G? Is UNII-3982TWQ96G safe for nursing mother and child? Does UNII-3982TWQ96G extracts into breast milk? Does UNII-3982TWQ96G has any long term or short term side effects on infants? Can UNII-3982TWQ96G influence milk supply or can UNII-3982TWQ96G decrease milk supply in lactating mothers?
UNII-3982TWQ96G lactation summary
- DrLact safety Score for UNII-3982TWQ96G is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of UNII-3982TWQ96G is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that UNII-3982TWQ96G does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of UNII-3982TWQ96G safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-3982TWQ96G usage in lactation
Reversible cholinesterase inhibitor used for treatment of Myasthenia gravis and as an analgesic adjuvant in epidural anesthesia (see specific info). It is not excreted into breastmilk (Fraser 1963, Wilson 1981).A breastfed neonate whose mother were treated with UNII-3982TWQ96G suffered of abdominal colicky pain after a feeding, but the UNII-3982TWQ96G plasma levels were undetectable (Fraser 1963). Because of a low oral bioavailability it seems even more unlikely the pass to the infant’s plasma through ingested breastmilk, except in preterm infants and immediate neonatal period, when there may be an increased intestinal permeability. On long-term treatments, because there is less published experience than with other drugs of the same group, a known safer alternative would be preferred during the neonatal period and/or in case of prematurity.
Answer by DrLact: About UNII-3982TWQ96G usage in lactation
Limited data indicate that use of UNII-3982TWQ96G to treat myasthenia gravis may be acceptable during breastfeeding, although pyridostigmine may be preferred. Monitor newborns because abdominal cramps after each breastfeeding has been reported. Because of its short half-life, single doses of UNII-3982TWQ96G to reverse neuromuscular blockade following surgery are unlikely to adversely affect the breastfed infant more than transiently.
UNII-3982TWQ96G Side Effects in Breastfeeding
Six infants of mothers treated with UNII-3982TWQ96G for myasthenia gravis were reportedly breastfed successfully. However, 1 newborn infant appeared to have abdominal cramps after each breastfeeding, probably caused by UNII-3982TWQ96G. UNII-3982TWQ96G could not be detected in the breastmilk of the infant's mother.[1]
UNII-3982TWQ96G Possible Effects in Breastfeeding
Relevant published information in nursing mothers was not found as of the revision date. In animals, cholinergic drugs increase oxytocin release,[2] and have variable effects on serum prolactin.[3] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.