Question

I am a breastfeeding mother and i want to know if it is safe to use Norfloxacin? Is Norfloxacin safe for nursing mother and child? Does Norfloxacin extracts into breast milk? Does Norfloxacin has any long term or short term side effects on infants? Can Norfloxacin influence milk supply or can Norfloxacin decrease milk supply in lactating mothers?

Norfloxacin lactation summary

Norfloxacin is safe in breastfeeding
  • DrLact safety Score for Norfloxacin is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Norfloxacin is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Norfloxacin does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Norfloxacin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Norfloxacin usage in lactation

Some published studies indicate that Norfloxacin is not excreted into breast milk. A short half life and low oral bioavailability are characteristics that suggest it is the safest quinolone-type antimicrobial to be used while breastfeeding. Quinolone antibiotics are being used to treat infection in newborn infants without side effect reported. A small amount pass into breast milk but absorption by the child's gut is thought would be interfered by the calcium present in the milk. Should Fluor-quinolone medication be used in breastfeeding mothers, Nofloxacin, Ofloxacin and Ciprofloxacin are considered to be of choice because a lower concentration in mother's serum. Follow-up of the child for the appearance of diarrhea is recommended since one case of Colitis pseudomembranosa occurred in a breastfed child who was born premature and complicated with Necrotizing Enterocolitis. Consider the possibility of false negative results of urine cultures among breastfed infants from treated mothers who are febrile.

Answer by DrLact: About Norfloxacin usage in lactation

No information is available on the clinical use of norfloxacin during breastfeeding; however, amounts in breastmilk appear to be low. Fluoroquinolones such as norfloxacin have traditionally not been used in infants because of concern about adverse effects on the infants' developing joints. However, recent studies indicate little risk.[1][2] In addition, the calcium in milk might prevent absorption of the small amounts of fluoroquinolones in milk,[3] but insufficient data exist to prove or disprove this assertion. The serum and milk levels and oral bioavailability of norfloxacin are the lowest of any of the fluoroquniolones, so the risk to the infant should be minimal. Use of norfloxacin is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash).

Alternate Drugs

Nafcillin(Safe)
Atovaquone(Low Risk)
Ritonavir(Unsafe)
Cefdinir(Safe)
Linezolid(Low Risk)
Lomefloxacin(Low Risk)
Nevirapine(Low Risk)
Cefazolin(Safe)
Enoxacin(Low Risk)
Naftifine(Safe)
Cefoxitin(Safe)
Abacavir(Safe)
Nelfinavir(Unsafe)
Moxifloxacin(Low Risk)
Doxycycline(Low Risk)
Ofloxacin(Safe)
Dapsone(Low Risk)
Cefotetan(Safe)
Levofloxacin(Low Risk)
Rifaximin(Safe)
Capreomycin(Low Risk)
Valganciclovir(Low Risk)
Famciclovir(Low Risk)
Cefaclor(Safe)
Ganciclovir(Low Risk)
Kanamycin(Safe)
Ertapenem(Safe)
Erythromycin(Low Risk)
Amikacin(Safe)
Indinavir(Unsafe)
Methicillin(Low Risk)
Demeclocycline(Low Risk)
Zidovudine(Low Risk)
Clindamycin(Low Risk)
Econazole(Safe)
Amantadine(Low Risk)
Tenofovir(Safe)
Cefixime(Safe)
Meropenem(Safe)
Lindane(Unsafe)
Neomycin(Safe)
Acyclovir(Safe)
Cefepime(Safe)
Quinine(Safe)
Saquinavir(Unsafe)
Efavirenz(Unsafe)
Gatifloxacin(Low Risk)
Primaquine(Low Risk)
Cefprozil(Safe)
Didanosine(Unsafe)
Aztreonam(Safe)
Malathion(Low Risk)
Cefdinir(Safe)
Lomefloxacin(Low Risk)
Cefazolin(Safe)
Enoxacin(Low Risk)
Cefoxitin(Safe)
Moxifloxacin(Low Risk)
Doxycycline(Low Risk)
Mupirocin(Safe)
Ofloxacin(Safe)
Cefotetan(Safe)
Levofloxacin(Low Risk)
Cefaclor(Safe)
Capreomycin(Low Risk)
Kanamycin(Safe)
Ertapenem(Safe)
Erythromycin(Low Risk)
Iodine(Unsafe)
Methicillin(Low Risk)
Demeclocycline(Low Risk)
Clindamycin(Low Risk)
Amikacin(Safe)
Methenamine(Unsafe)
Cefixime(Safe)
Neomycin(Safe)
Cefepime(Safe)
Nalidixic Acid(Low Risk)
Gatifloxacin(Low Risk)
Cefprozil(Safe)
Aztreonam(Safe)
Nafcillin(Safe)
Enoxacin(Low Risk)
Moxifloxacin(Low Risk)
Ofloxacin(Safe)
Levofloxacin(Low Risk)
Gatifloxacin(Low Risk)
Lomefloxacin(Low Risk)
Enoxacin(Low Risk)
Moxifloxacin(Low Risk)
Ofloxacin(Safe)
Levofloxacin(Low Risk)
Nalidixic Acid(Low Risk)
Gatifloxacin(Low Risk)
Lomefloxacin(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.