Is Granulocyte colony stimulating factor, recombinant Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Granulocyte colony stimulating factor, recombinant? Is Granulocyte colony stimulating factor, recombinant safe for nursing mother and child? Does Granulocyte colony stimulating factor, recombinant extracts into breast milk? Does Granulocyte colony stimulating factor, recombinant has any long term or short term side effects on infants? Can Granulocyte colony stimulating factor, recombinant influence milk supply or can Granulocyte colony stimulating factor, recombinant decrease milk supply in lactating mothers?

Non-glycosylated stimulating factor of granulocyte colonies (G-CSF) which is obtained by recombinant technology.The naturally occurring product is found in breast milk. A very high molecular weight explains the insignificant or no excretion into milk that has been observed both with Lenograstim and Granulocyte colony stimulating factor, recombinant. Its low oral bioavailability hampers absorption into infant plasma from the breast milk ingested, as for their proteic nature it is degraded in the gastrointestinal tract, not being absorbed. Granulocyte colony stimulating factor, recombinant is not absorbed by the infant's gut even during the neonatal period or prematurity. The granulocyte colony-stimulating factor has been used in premature newborns, both on prevention and treatment of neonatal sepsis and/or necrotizing enterocolitis without adverse effects being observed among treated infants. The bovine G-CSF is found in the usual diet of meat eaters.

Granulocyte colony stimulating factor, recombinant in the pharmaceutical name for granulocyte colony-stimulating factor (G-CSF). PegGranulocyte colony stimulating factor, recombinant is the long-acting form of Granulocyte colony stimulating factor, recombinant. The excretion of exogenous G-CSF into breastmilk or its effects on breastfed infants have not been well studied. Limited data indicate that Granulocyte colony stimulating factor, recombinant and a similar G-CSF product, lenograstim, are poorly excreted into breastmilk and are undetectable by 3 days after an injection. Some authors recommend withholding breastfeeding for this period of time.[1] However, Granulocyte colony stimulating factor, recombinant has been safely given orally to neonates and is not orally absorbed by neonates, so any Granulocyte colony stimulating factor, recombinant that is excreted into milk is unlikely to adversely affect the breastfed infant.

Published information on the effects of Granulocyte colony stimulating factor, recombinant in breastmilk was not found as of the revision date. However, oral Granulocyte colony stimulating factor, recombinant 20 mcg daily for 5 days has been given to preterm infants with stage I necrotizing enterocolitis (NEC). Granulocyte colony stimulating factor, recombinant appeared to halt progression to more severe stages of NEC in this small study.[6]