Is UNII-PVI5M0M1GW Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-PVI5M0M1GW? Is UNII-PVI5M0M1GW safe for nursing mother and child? Does UNII-PVI5M0M1GW extracts into breast milk? Does UNII-PVI5M0M1GW has any long term or short term side effects on infants? Can UNII-PVI5M0M1GW influence milk supply or can UNII-PVI5M0M1GW decrease milk supply in lactating mothers?
UNII-PVI5M0M1GW lactation summary
- DrLact safety Score for UNII-PVI5M0M1GW is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of UNII-PVI5M0M1GW is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that UNII-PVI5M0M1GW does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of UNII-PVI5M0M1GW safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-PVI5M0M1GW usage in lactation
Non-glycosylated stimulating factor of granulocyte colonies (G-CSF) which is obtained by recombinant technology.The naturally occurring product is found in breast milk. A very high molecular weight explains the insignificant or no excretion into milk that has been observed both with Lenograstim and UNII-PVI5M0M1GW. Its low oral bioavailability hampers absorption into infant plasma from the breast milk ingested, as for their proteic nature it is degraded in the gastrointestinal tract, not being absorbed. UNII-PVI5M0M1GW is not absorbed by the infant's gut even during the neonatal period or prematurity. The granulocyte colony-stimulating factor has been used in premature newborns, both on prevention and treatment of neonatal sepsis and/or necrotizing enterocolitis without adverse effects being observed among treated infants. The bovine G-CSF is found in the usual diet of meat eaters.
Answer by DrLact: About UNII-PVI5M0M1GW usage in lactation
UNII-PVI5M0M1GW in the pharmaceutical name for granulocyte colony-stimulating factor (G-CSF). PegUNII-PVI5M0M1GW is the long-acting form of UNII-PVI5M0M1GW. The excretion of exogenous G-CSF into breastmilk or its effects on breastfed infants have not been well studied. Limited data indicate that UNII-PVI5M0M1GW and a similar G-CSF product, lenograstim, are poorly excreted into breastmilk and are undetectable by 3 days after an injection. Some authors recommend withholding breastfeeding for this period of time.[1] However, UNII-PVI5M0M1GW has been safely given orally to neonates and is not orally absorbed by neonates, so any UNII-PVI5M0M1GW that is excreted into milk is unlikely to adversely affect the breastfed infant.
UNII-PVI5M0M1GW Side Effects in Breastfeeding
Published information on the effects of UNII-PVI5M0M1GW in breastmilk was not found as of the revision date. However, oral UNII-PVI5M0M1GW 20 mcg daily for 5 days has been given to preterm infants with stage I necrotizing enterocolitis (NEC). UNII-PVI5M0M1GW appeared to halt progression to more severe stages of NEC in this small study.[6]