Is Filgrastim Hexal Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Filgrastim Hexal? Is Filgrastim Hexal safe for nursing mother and child? Does Filgrastim Hexal extracts into breast milk? Does Filgrastim Hexal has any long term or short term side effects on infants? Can Filgrastim Hexal influence milk supply or can Filgrastim Hexal decrease milk supply in lactating mothers?
Filgrastim Hexal lactation summary
- DrLact safety Score for Filgrastim Hexal is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Filgrastim Hexal is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Filgrastim Hexal does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Filgrastim Hexal safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Filgrastim Hexal usage in lactation
Non-glycosylated stimulating factor of granulocyte colonies (G-CSF) which is obtained by recombinant technology.The naturally occurring product is found in breast milk. A very high molecular weight explains the insignificant or no excretion into milk that has been observed both with Lenograstim and Filgrastim Hexal. Its low oral bioavailability hampers absorption into infant plasma from the breast milk ingested, as for their proteic nature it is degraded in the gastrointestinal tract, not being absorbed. Filgrastim Hexal is not absorbed by the infant's gut even during the neonatal period or prematurity. The granulocyte colony-stimulating factor has been used in premature newborns, both on prevention and treatment of neonatal sepsis and/or necrotizing enterocolitis without adverse effects being observed among treated infants. The bovine G-CSF is found in the usual diet of meat eaters.
Answer by DrLact: About Filgrastim Hexal usage in lactation
Filgrastim Hexal in the pharmaceutical name for granulocyte colony-stimulating factor (G-CSF). PegFilgrastim Hexal is the long-acting form of Filgrastim Hexal. The excretion of exogenous G-CSF into breastmilk or its effects on breastfed infants have not been well studied. Limited data indicate that Filgrastim Hexal and a similar G-CSF product, lenograstim, are poorly excreted into breastmilk and are undetectable by 3 days after an injection. Some authors recommend withholding breastfeeding for this period of time.[1] However, Filgrastim Hexal has been safely given orally to neonates and is not orally absorbed by neonates, so any Filgrastim Hexal that is excreted into milk is unlikely to adversely affect the breastfed infant.
Filgrastim Hexal Side Effects in Breastfeeding
Published information on the effects of Filgrastim Hexal in breastmilk was not found as of the revision date. However, oral Filgrastim Hexal 20 mcg daily for 5 days has been given to preterm infants with stage I necrotizing enterocolitis (NEC). Filgrastim Hexal appeared to halt progression to more severe stages of NEC in this small study.[6]