Is 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-? Is 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- safe for nursing mother and child? Does 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- extracts into breast milk? Does 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- has any long term or short term side effects on infants? Can 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- influence milk supply or can 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- decrease milk supply in lactating mothers?

Answer by DrLact: About 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- usage in lactation

No information is available on the clinical use of 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- during breastfeeding. The manufacturer recommends that breastfeeding be discontinued during 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)- therapy and for 7 days after the last dose.

Alternate Drugs

Cobimetinib

Cetuximab(Unsafe)

Etoposide(Dangerous)

Gefitinib

Acalabrutinib

Bleomycin(Dangerous)

Avelumab

Carboplatin(Dangerous)

Moxetumomab Pasudotox

Doxorubicin(Dangerous)

Vinorelbine(Dangerous)

Imatinib(Unsafe)

Paclitaxel(Dangerous)

Topotecan

Crizotinib

Cyclophosphamide(Dangerous)

Dacarbazine(Dangerous)

Fluorouracil(Dangerous)

Cisplatin(Unsafe)

Azelaic Acid(Safe)

Dasatinib(Unsafe)

Alemtuzumab(Low Risk)

Dactinomycin(Dangerous)

Busulfan(Dangerous)

Docetaxel(Dangerous)

Rituximab(Low Risk)

Bevacizumab(Low Risk)

Copanlisib

Thioguanine(Dangerous)

Nintedanib

Gemcitabine(Dangerous)

Pazopanib(Unsafe)

Nilotinib(Unsafe)

Vincristine(Dangerous)

Letrozole(Dangerous)

Tamoxifen(Dangerous)

Erlotinib(Unsafe)

Emicizumab

Daratumumab

Trastuzumab(Unsafe)

Ado-Trastuzumab Emtansine

Exemestane(Dangerous)

Idelalisib

Obinutuzumab

Mitoxantrone(Dangerous)

Dinutuximab

Midostaurin

Regorafenib

Cladribine(Dangerous)

Inotuzumab Ozogamicin

Mercaptopurine(Safe)

Nivolumab(Unsafe)

Ipilimumab(Unsafe)

Hydroxyurea(Low Risk)

Vinblastine(Dangerous)

Imatinib(Unsafe)

Dasatinib(Unsafe)

Orlistat(Low Risk)

Gemcitabine(Dangerous)

Pazopanib(Unsafe)

Nilotinib(Unsafe)

Allopurinol(Safe)

Erlotinib(Unsafe)

Dasatinib(Unsafe)

Pazopanib(Unsafe)

Nilotinib(Unsafe)

Erlotinib(Unsafe)

Imatinib(Unsafe)

Dasatinib(Unsafe)

Pazopanib(Unsafe)

Nilotinib(Unsafe)

Erlotinib(Unsafe)

Imatinib(Unsafe)

Pazopanib(Unsafe)

Nilotinib(Unsafe)

Erlotinib(Unsafe)

Imatinib(Unsafe)

Dasatinib(Unsafe)

Synonyms of 2H-4,8-Methenopyrazolo(4,3-H)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-

UNII-OSP71S83EU

PF-06463922

Loratinib

7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11)benzoxadiazacyclotetradecine-3-carbonitrile

PF 06463922

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.