Is U0279 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use U0279? Is U0279 safe for nursing mother and child? Does U0279 extracts into breast milk? Does U0279 has any long term or short term side effects on infants? Can U0279 influence milk supply or can U0279 decrease milk supply in lactating mothers?

• DrLact safety Score for U0279 is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of U0279 may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that U0279 may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using U0279 .
• It is recommended to evaluate the advantage of not breastfeeding while using U0279 Vs not using U0279 And continue breastfeeding.
• While using U0279 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Synthetic retinoid derivated from vitamin A. Despite a low amount secreted through the breast milk (<2% of the equivalent maternal dose), some authorities think that product's toxicity justifies to avoid it during breastfeeding. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Limited information indicates that maternal doses of U0279 of 0.65 mg/kg daily produce low levels in milk. Because there is no published experience with U0279 during breastfeeding, opinions vary on the advisability of breastfeeding during U0279 therapy.[1][2][3] Various topical agents that are less likely to be absorbed by the mother may be preferred during breastfeeding, especially while nursing a newborn or preterm infant. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[4]

A review of adverse reaction reports on retinoids causing a breast reaction submitted to a French pharmacovigilance center found 8 cases of gynecomastia was associated with U0279 use.[5]