Is Gadodiamide hydrate Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Gadodiamide hydrate? Is Gadodiamide hydrate safe for nursing mother and child? Does Gadodiamide hydrate extracts into breast milk? Does Gadodiamide hydrate has any long term or short term side effects on infants? Can Gadodiamide hydrate influence milk supply or can Gadodiamide hydrate decrease milk supply in lactating mothers?

Gadolinium chelate that has a similar action and use than gadopentetic acid.At latest update no published data on excretion into breast milk were found. It has been used in the pediatric age. The various contrast media that are gadolinium derivatives and used for explorations with Magnetic Resonance Imaging (MRI) are considered compatible with breastfeeding because they are quickly eliminated (elimination half-life of less than 2 hours). They undergo very little metabolic changes and are virtually non-absorbable orally. They are structurally very similar to each other. Some have been shown to have no or minimal excretion into the milk. Less than 0.04% of the dose given to the mother ends just going into the milk.Due to its low oral bioavailability, intestinal absorption should be less than 1% of the dose took by the infant.The maximum dose received by the infant is considered less than 0.0004% of the maternal dose, which is much less than the dose administered to a newborn infant who undergoes a MRI scan. Most Radiology Scientific Societies agree that after an MRI scan is not necessary to temporarily stop breastfeeding. Some authors recommend avoiding the use on lactating women of some Gadolinium contrast media that would pose a high risk for developing Systemic Nephrogenic Fibrosis, especially in the neonatal period, like gadoversetamide, and Gadodiamide hydrate dimeglumine, by using instead low-risk ones like gadoterate, gadoteridol and gadobutrol.

Gadodiamide hydrate releases more free gadolinium than most other gadolinium-containing contrast agents and European sources recommend that the mother pump and discard milk for 24 hours after receiving Gadodiamide hydrate.[1][2] However, guidelines developed by several North American professional organizations state that breastfeeding need not be disrupted after a nursing mother receives a gadolinium-containing contrast medium.[3][4][5] Other agents may be preferred, especially while nursing a newborn or preterm infant.

A mother with neuromyelitis optica was nursing her 38-day-old male infant. Each breastfeeding session was about 15 minutes in every 2 hours. She was given Gadodiamide hydrate (dose not specified) before an MRI scan. She withheld breastfeeding for 6 to 8 hours after the injection. Her infant experienced no immediate adverse effects.[6]