Question

I am a breastfeeding mother and i want to know if it is safe to use Isovue-M 300? Is Isovue-M 300 safe for nursing mother and child? Does Isovue-M 300 extracts into breast milk? Does Isovue-M 300 has any long term or short term side effects on infants? Can Isovue-M 300 influence milk supply or can Isovue-M 300 decrease milk supply in lactating mothers?

Isovue-M 300 lactation summary

Isovue-M 300 is safe in breastfeeding
  • DrLact safety Score for Isovue-M 300 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Isovue-M 300 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Isovue-M 300 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Isovue-M 300 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Isovue-M 300 usage in lactation

X-ray contrast medium that contains 49% of Iodine. At latest update no published data were found on excretion into breast milk. It is also used in the pediatric age. The various iodinated contrast media for imaging examinations (X-rays, CT scans) are considered compatible with breastfeeding since they are rapidly eliminated with little or no release of iodine, not metabolized and virtually not absorbed when taken by mouth. They are structurally very similar to each other and one of them is their data no or minimal excretion in milk. Given the low lipid solubility of the iodinated contrast, less than 1% of the dose administered to the mother just passing milk.Due to their low oral bioavailability, intestinal absorption is less than 1% of the dose that he may take the infant.The maximum dose just getting the baby is less than 0.01% of the maternal dose, which represents less than 1% of the dose administered to a nursing practice that is a radiological contrast examination. Most radiology scientific societies agree that after a radiological iodinated contrast examination is not necessary to wait any time to resume nursing.

Answer by DrLact: About Isovue-M 300 usage in lactation

Intravenous iodinated contrast media are poorly excreted into breastmilk and poorly absorbed orally so they are not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Guidelines developed by several professional organizations state that breastfeeding need not be disrupted after a nursing mother receives a iodine-containing contrast medium.[1][2][3][4] However, because there is no published experience with Isovue-M 300 during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.