Question

I am a breastfeeding mother and i want to know if it is safe to use Mestranol + Norethindrone? Is Mestranol + Norethindrone safe for nursing mother and child? Does Mestranol + Norethindrone extracts into breast milk? Does Mestranol + Norethindrone has any long term or short term side effects on infants? Can Mestranol + Norethindrone influence milk supply or can Mestranol + Norethindrone decrease milk supply in lactating mothers?

Mestranol + Norethindrone lactation summary

Mestranol + Norethindrone usage has low risk in breastfeeding
  • DrLact safety Score for Mestranol + Norethindrone is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Mestranol + Norethindrone may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Mestranol + Norethindrone may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Mestranol + Norethindrone low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Mestranol + Norethindrone We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Mestranol + Norethindrone usage in lactation

Birth control pill that contains the combination of an estrogen (Mestranol) and a progestin (Noretindrone) for oral use. Mestranol is a synthetic estrogen that is metabolized to Ethinylestradiol with similar actions as estradiol. A latest update no published data on excretion in breast milk, found were found. However, it is known that its metabolite Ethinylestradiol is excreted into milk in no or small amount.There is evidence (albeit inconsistent) that estrogen-containing pills may decrease milk production, especially during the first few weeks postpartum with a daily dose above 30 micrograms of ethinyl estradiol.It may reduce the protein content of the milk.No problems have been observed in infants whose mothers were treated, except one isolated case of transient gynecomastia. Norethindrone or Norethisterone is a progestin derivative of 19-nortestosterone. It is excreted in breast milk in clinically non-significant amount and no problems have been observed in infants whose mothers were treated with it. Its plasma levels in these infants were undetectable or very low. With other similar combined contraceptives no differences have been observed in the frequency of breastfeeding or the amount of milk produced or weight gain of breastfed infants compared to other contraceptive methods (intrauterine devices, isolated progestogens). However, it would be advisable to avoid them until breastfeeding is well established (4-6 weeks). During lactation, progestin-only contraceptive pills are preferred to Estrogen containing ones, otherwise, the lowest estrogen dose should be used.Within the first 6 postpartum weeks, non-hormonal methods are in the first line of choice. Hormone containing contraceptives do not affect the composition of milk, minerals (Mg, Fe, Cu, Ca, P) fat, lactose and calories but only a few the proteins.
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