Is Pioglitazone Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Pioglitazone? Is Pioglitazone safe for nursing mother and child? Does Pioglitazone extracts into breast milk? Does Pioglitazone has any long term or short term side effects on infants? Can Pioglitazone influence milk supply or can Pioglitazone decrease milk supply in lactating mothers?
Pioglitazone lactation summary
- DrLact safety Score for Pioglitazone is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Pioglitazone may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Pioglitazone may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Pioglitazone low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Pioglitazone We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Pioglitazone usage in lactation
Tiazolidindion drugs increase response to insulin.Oral anti-diabetic drugs are useless as treatment of diabetes type 1. For diabetes type 2, diet and exercise are advisable. Breastfeeding helps to lower glucemia level. See section on Maternal diabetes mellitus
Answer by DrLact: About Pioglitazone usage in lactation
No information is available on the clinical use of pioglitazone during breastfeeding. Pioglitazone is over 99% protein bound in plasma, so it is unlikely to pass into breastmilk in clinically important amounts. If pioglitazone is required by the mother, it is not a reason to discontinue breastfeeding. However, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Alternate Drugs
Acarbose(Safe)
Miglitol(Safe)
Tolbutamide(Safe)
Dulaglutide(Low Risk)
Rosiglitazone(Low Risk)
Liraglutide(Low Risk)
Repaglinide(Unsafe)
Pioglitazone(Low Risk)
Nateglinide(Unsafe)
Empagliflozin(Unsafe)
Metformin(Safe)
Dapagliflozin(Unsafe)
Insulin(Safe)
Alogliptin(Low Risk)
Glyburide(Safe)
Glipizide(Safe)
Linagliptin(Low Risk)
Glimepiride(Unsafe)
Sitagliptin(Low Risk)
Chlorpropamide(Low Risk)
Saxagliptin(Low Risk)
Acetohexamide(Low Risk)
Colesevelam(Safe)
Rosiglitazone(Low Risk)
Pioglitazone(Low Risk)