Is (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester? Is (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester safe for nursing mother and child? Does (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester extracts into breast milk? Does (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester has any long term or short term side effects on infants? Can (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester influence milk supply or can (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester decrease milk supply in lactating mothers?
(11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester lactation summary
- DrLact safety Score for (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester usage in lactation
Prostaglandin E1 analogue that is used in the prevention of gastroduodenal ulcers associated with the use of NSAIDs and induction of labor and abortion provocation. It is found naturally in milk and colostrum. It is excreted in breast milk in clinically non-significant amount with a very short half-life span. Follow-up for intestinal colic or diarrhea in the infant.
Answer by DrLact: About (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester usage in lactation
Mispoprostol is a prostaglandin E1 analogue. Prostaglandin E1 and other prostaglandins appear normally in colostrum and milk.[1] Because of the extremely low levels of (11-alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid methyl ester in breastmilk, amounts ingested by the infant are trivial and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.
Alternate Drugs
Methotrexate(Low Risk)
Misoprostol(Safe)
Ranitidine(Safe)
Sucralfate(Safe)
Omeprazole(Safe)
Nizatidine(Safe)
Dexlansoprazole(Safe)
Famotidine(Safe)
Cimetidine(Low Risk)
Rabeprazole(Safe)
Pantoprazole(Safe)
Misoprostol(Safe)
Lansoprazole(Safe)
Esomeprazole(Safe)
Bisacodyl(Safe)
Ursodiol(Safe)
Sucralfate(Safe)
Omeprazole(Safe)
Certolizumab Pegol(Safe)
Rifaximin(Safe)
Senna(Safe)
Nizatidine(Safe)
Droperidol(Low Risk)
Sulfasalazine(Safe)
Dexlansoprazole(Safe)
Olsalazine(Safe)
Metoclopramide(Safe)
Famotidine(Safe)
Mesalamine(Safe)
Peppermint(Safe)
Alosetron(Low Risk)
Cisapride(Safe)
Loperamide(Safe)
Trimethobenzamide(Unsafe)
Cimetidine(Low Risk)
Rabeprazole(Safe)
Cyclizine(Low Risk)
Magnesium Sulfate(Safe)
Octreotide(Safe)
Magnesium Hydroxide(Safe)
Thiethylperazine(Unsafe)
Misoprostol(Safe)
Pantoprazole(Safe)
Infliximab(Safe)
Linaclotide(Safe)
Prochlorperazine(Unsafe)
Etanercept(Safe)
Lansoprazole(Safe)
Docusate(Safe)
Doxylamine(Unsafe)
Dimenhydrinate(Low Risk)
Magnesium Oxide(Safe)
Esomeprazole(Safe)
Cascara Sagrada(Low Risk)
Adalimumab(Safe)
Sodium Picosulfate(Safe)
Domperidone(Safe)
Ranitidine(Safe)
Dinoprostone(Low Risk)
Methylergonovine(Low Risk)
Oxytocin(Safe)
Misoprostol(Safe)
Bimatoprost(Safe)
Travoprost(Safe)
Misoprostol(Safe)
Latanoprost(Safe)
Dinoprostone(Low Risk)