Is 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione? Is 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione safe for nursing mother and child? Does 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione extracts into breast milk? Does 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione has any long term or short term side effects on infants? Can 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione influence milk supply or can 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione decrease milk supply in lactating mothers?

Limited information indicates that maternal doses of 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione up to 45 mg daily produce low levels in milk. Because no information is available on the long-term use of 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Possible drug-induced seizure-like activity and cyanosis occurred in a breastfed 3-week-old whose mother was taking 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione 15 mg 3 times daily as well as fluoxetine and carbamazepine during pregnancy and breastfeeding. The authors thought that this reaction, if drug induced, was most likely caused by fluoxetine.[1] One exclusively breastfed 11-week-old infant was breastfed during maternal therapy with 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione 10 mg daily and venlafaxine 300 mg daily. No adverse reactions were reported by the mother or in the medical records.[2]

8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione increases serum prolactin.[3][4][5][6] Galactorrhea was reported in a women taking venlafaxine after 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione was added to her regimen. However, when 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione was discontinued, galactorrhea persisted.[7] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.