Question

I am a breastfeeding mother and i want to know if it is safe to use UNII-TK65WKS8HL? Is UNII-TK65WKS8HL safe for nursing mother and child? Does UNII-TK65WKS8HL extracts into breast milk? Does UNII-TK65WKS8HL has any long term or short term side effects on infants? Can UNII-TK65WKS8HL influence milk supply or can UNII-TK65WKS8HL decrease milk supply in lactating mothers?

Answer by DrLact: About UNII-TK65WKS8HL usage in lactation

Limited information indicates that maternal doses of UNII-TK65WKS8HL up to 45 mg daily produce low levels in milk. Because no information is available on the long-term use of UNII-TK65WKS8HL during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

UNII-TK65WKS8HL Side Effects in Breastfeeding

Possible drug-induced seizure-like activity and cyanosis occurred in a breastfed 3-week-old whose mother was taking UNII-TK65WKS8HL 15 mg 3 times daily as well as fluoxetine and carbamazepine during pregnancy and breastfeeding. The authors thought that this reaction, if drug induced, was most likely caused by fluoxetine.[1] One exclusively breastfed 11-week-old infant was breastfed during maternal therapy with UNII-TK65WKS8HL 10 mg daily and venlafaxine 300 mg daily. No adverse reactions were reported by the mother or in the medical records.[2]

UNII-TK65WKS8HL Possible Effects in Breastfeeding

UNII-TK65WKS8HL increases serum prolactin.[3][4][5][6] Galactorrhea was reported in a women taking venlafaxine after UNII-TK65WKS8HL was added to her regimen. However, when UNII-TK65WKS8HL was discontinued, galactorrhea persisted.[7] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs

Clorazepate(Low Risk)
Meprobamate(Low Risk)
Alprazolam(Low Risk)
Temazepam(Low Risk)
Quazepam(Unsafe)
Oxazepam(Safe)
Midazolam(Safe)
Nitrazepam(Low Risk)
Lorazepam(Safe)
Diazepam(Low Risk)
Zolmitriptan(Low Risk)
Rizatriptan(Low Risk)
Naratriptan(Low Risk)
Frovatriptan(Low Risk)
Almotriptan(Low Risk)
Cisapride(Safe)
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