Is 4-04-00-01242 (Beilstein Handbook Reference) Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 4-04-00-01242 (Beilstein Handbook Reference)? Is 4-04-00-01242 (Beilstein Handbook Reference) safe for nursing mother and child? Does 4-04-00-01242 (Beilstein Handbook Reference) extracts into breast milk? Does 4-04-00-01242 (Beilstein Handbook Reference) has any long term or short term side effects on infants? Can 4-04-00-01242 (Beilstein Handbook Reference) influence milk supply or can 4-04-00-01242 (Beilstein Handbook Reference) decrease milk supply in lactating mothers?
4-04-00-01242 (Beilstein Handbook Reference) lactation summary
- DrLact safety Score for 4-04-00-01242 (Beilstein Handbook Reference) is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of 4-04-00-01242 (Beilstein Handbook Reference) may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that 4-04-00-01242 (Beilstein Handbook Reference) may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of 4-04-00-01242 (Beilstein Handbook Reference) low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using 4-04-00-01242 (Beilstein Handbook Reference) We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 4-04-00-01242 (Beilstein Handbook Reference) usage in lactation
Copper chelator used in the treatment of Wilson's disease. It is excreted in breast milk in clinically insignificant amounts (undetectable levels: Izumi 2012). Copper and zinc levels in breastmilk of mothers treated with penicillamine, 4-04-00-01242 (Beilstein Handbook Reference) or zinc are normal (Izumi 2012). Oral bioavailability, which is very low during periods of fasting, is practically non-existent in the presence of food, especially milk, so it would be very difficult to pass into the infant plasma from the ingested breast milk (PDR 2016).
Answer by DrLact: About 4-04-00-01242 (Beilstein Handbook Reference) usage in lactation
Limited information indicates that 4-04-00-01242 (Beilstein Handbook Reference) is not detectable in breastmilk. The effect of 4-04-00-01242 (Beilstein Handbook Reference) on breastmilk copper and zinc concentrations in milk is conflicting,[1][2][3] but breastfed infants appear to have normal serum copper and zinc plasma levels. Based on available data, it appears that 4-04-00-01242 (Beilstein Handbook Reference) is acceptable to use during breastfeeding.
4-04-00-01242 (Beilstein Handbook Reference) Side Effects in Breastfeeding
Three infants were breastfed during maternal treatment of Wilson's disease with 4-04-00-01242 (Beilstein Handbook Reference). Serum zinc and copper concentrations were normal in these infants.[3] A center in Turkey reported 23 infants born to mothers with Wilson's disease over a 20-year period. One patient was treated with 600 mg of 4-04-00-01242 (Beilstein Handbook Reference) plus 100 mg of zinc daily. All of the infants were breastfed (extent and duration not specified). One premature infant died at 3 weeks of age (maternal drug not specified), but the other infants had no apparent complications over a median of 51 months (range 13 to 105 months) of follow-up.[4]
4-04-00-01242 (Beilstein Handbook Reference) Possible Effects in Breastfeeding
Conflicting data exist on breastmilk concentrations of zinc and copper during therapy of Wilson's disease with 4-04-00-01242 (Beilstein Handbook Reference). One abstract reported that breastmilk concentrations were normal during therapy,[2] but another abstract from the same authors reported lower milk concentrations of zinc and copper.[1]