Is Triethylenetetramine Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Triethylenetetramine? Is Triethylenetetramine safe for nursing mother and child? Does Triethylenetetramine extracts into breast milk? Does Triethylenetetramine has any long term or short term side effects on infants? Can Triethylenetetramine influence milk supply or can Triethylenetetramine decrease milk supply in lactating mothers?
Triethylenetetramine lactation summary
- DrLact safety Score for Triethylenetetramine is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Triethylenetetramine may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Triethylenetetramine may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Triethylenetetramine low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Triethylenetetramine We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Triethylenetetramine usage in lactation
Copper chelator used in the treatment of Wilson's disease. It is excreted in breast milk in clinically insignificant amounts (undetectable levels: Izumi 2012). Copper and zinc levels in breastmilk of mothers treated with penicillamine, Triethylenetetramine or zinc are normal (Izumi 2012). Oral bioavailability, which is very low during periods of fasting, is practically non-existent in the presence of food, especially milk, so it would be very difficult to pass into the infant plasma from the ingested breast milk (PDR 2016).
Answer by DrLact: About Triethylenetetramine usage in lactation
Limited information indicates that Triethylenetetramine is not detectable in breastmilk. The effect of Triethylenetetramine on breastmilk copper and zinc concentrations in milk is conflicting,[1][2][3] but breastfed infants appear to have normal serum copper and zinc plasma levels. Based on available data, it appears that Triethylenetetramine is acceptable to use during breastfeeding.
Triethylenetetramine Side Effects in Breastfeeding
Three infants were breastfed during maternal treatment of Wilson's disease with Triethylenetetramine. Serum zinc and copper concentrations were normal in these infants.[3] A center in Turkey reported 23 infants born to mothers with Wilson's disease over a 20-year period. One patient was treated with 600 mg of Triethylenetetramine plus 100 mg of zinc daily. All of the infants were breastfed (extent and duration not specified). One premature infant died at 3 weeks of age (maternal drug not specified), but the other infants had no apparent complications over a median of 51 months (range 13 to 105 months) of follow-up.[4]
Triethylenetetramine Possible Effects in Breastfeeding
Conflicting data exist on breastmilk concentrations of zinc and copper during therapy of Wilson's disease with Triethylenetetramine. One abstract reported that breastmilk concentrations were normal during therapy,[2] but another abstract from the same authors reported lower milk concentrations of zinc and copper.[1]