Is Piperidolate Hydrochloride Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Piperidolate Hydrochloride? Is Piperidolate Hydrochloride safe for nursing mother and child? Does Piperidolate Hydrochloride extracts into breast milk? Does Piperidolate Hydrochloride has any long term or short term side effects on infants? Can Piperidolate Hydrochloride influence milk supply or can Piperidolate Hydrochloride decrease milk supply in lactating mothers?
Piperidolate Hydrochloride lactation summary
- DrLact safety Score for Piperidolate Hydrochloride is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Piperidolate Hydrochloride may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Piperidolate Hydrochloride may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Piperidolate Hydrochloride low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Piperidolate Hydrochloride We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Piperidolate Hydrochloride usage in lactation
t is a tertiary amine with antimuscarinic/anticholinergic effects, with an action similar to atropine. It has smooth muscle antispasmodic properties. Administered for gastroenteritis, duodenal ulcer, biliary conditions, dysmenorrhea and treatment of miscarriage and premature birth (Kyorin 2013, Sanofi 2010). Since the last update we have not found published data on its excretion in breast milk. There is hardly any published scientific data on this product: there are only 6 studies and the most recent dates from 1977. There is no pharmacokinetic data except that it has good absorption in the digestive tract (Sanofi 2010). Other anticholinergics from the same family such as tolterodine have high protein binding, which would make it unlikely that it passes into milk in significant amounts. Atropine in isolated doses is considered compatible with breastfeeding. During breastfeeding it may be prudent to avoid or take short-term and minimal doses, monitoring milk production as anticholinergics may reduce milk production (De Martino 1980, Bizarro 1980), especially the first few weeks postpartum. It is also advisable to monitor anticholinergic symptoms in the infant (dry mouth, constipation ..). See below the information of these related products:
Alternate Drugs for Drugs for functional bowel disorders (Anticholinergics, Antispasmodics). ATC A03A-B,
Dicyclomine(Unsafe)
Atropine(Safe)
Glycopyrrolate(Unsafe)
Belladona(Unsafe)
Dicycloverine(Unsafe)
Phloroglucinol(Low Risk)
Otilonium Bromide(Safe)
Glycopyrronium Bromide(Unsafe)
Hyoscyamine(Low Risk)
Mebeverine Hydrochloride(Low Risk)
Pinaverium Bromide(Low Risk)
Prifinium Bromide(Low Risk)
Propantheline-Bromide(Low Risk)
Trimebutine maleate(Low Risk)
Phloroglucin(Low Risk)
Daturine(Low Risk)