Is HSDB 7458 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use HSDB 7458? Is HSDB 7458 safe for nursing mother and child? Does HSDB 7458 extracts into breast milk? Does HSDB 7458 has any long term or short term side effects on infants? Can HSDB 7458 influence milk supply or can HSDB 7458 decrease milk supply in lactating mothers?

Extracted from Artemisia annua a plant that is used in China for malaria treatment. It has been included in WHO’s Model List of Essential Drug and considered a suitable medication during breastfeeding. Extraídos de la Artemisia annua, planta utilizada en China contra el paludismo. Considerada medicación esencial compatible con la lactancia por la OMS. Se utiliza asociado a lumefantrina (Coartem) para el tratamiento del paludismo por plasmodium falciparum sin complicaciones.

Limited information indicates that a maternal dose of 200 mg orally produced low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Withholding breastfeeding for 6 hour after a dose should markedly reduce the dose the infant receives. In general, very small amounts of antimalarial drugs are excreted in the breast milk of lactating women. Because the quantity of antimalarial drugs transferred in breast milk is insufficient to provide adequate protection against malaria, infants who require chemoprophylaxis must receive the recommended dosages of antimalarial drugs.[1]

Breastfed infants who were given dihydroartemisinin and piperaquine as a treatment for malaria had a higher frequency of vomiting than non-breastfed infants given the drugs. Whether this finding applies to infants who receive dihydroartemisinin via breastmilk has not been studied.[3]