Is BX 661A Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use BX 661A? Is BX 661A safe for nursing mother and child? Does BX 661A extracts into breast milk? Does BX 661A has any long term or short term side effects on infants? Can BX 661A influence milk supply or can BX 661A decrease milk supply in lactating mothers?

Prodrug of Mesalamine: medication compounded by Mesalazine and an inert transporter that is degraded by bacteria into Mesalazine (5-ASA) in the large intestine. It is badly absorbed by the intestine, serum levels are low with scant excretion into breast milk. No harm effects among breastfed infants from treated mothers have been reported, except for rare cases of diarrhea reported in the 80's with the use of Mesalazine compounds different to BX 661A. In a review of 121 cases and 121 controls, the authors failed to observe those findings. (Moretti, 1989). Expert consensus supports the compatibility of Mesalazine and/or its prodrugs during breastfeeding.

Although no information exists on the excretion of BX 661A into breastmilk, it is metabolized to the active drug mesalamine. A few cases of diarrhea have been reported in infants exposed to mesalamine, although the rate is not high. Most experts consider mesalamine derivatives to be safe during breastfeeding.[1][2][3][4] If BX 661A is required by the mother, it is not a reason to discontinue breastfeeding, but observe breastfed infants for diarrhea.

The active metabolite of BX 661A, mesalamine, was probably responsible for diarrhea in a 6-week-old whose diarrhea recurred 4 times after rechallenge of the mother 4 times during breastfeeding.[5] Diarrhea has also been reported anecdotally by some nursing mothers taking mesalamine,[6] but a small controlled study reported only in abstract form found no higher rate of diarrhea in the breastfed infants of mothers taking mesalamine than in control infants.[7]