I am a breastfeeding mother and i want to know if it is safe to use Prochlorperazine? Is Prochlorperazine safe for nursing mother and child? Does Prochlorperazine extracts into breast milk? Does Prochlorperazine has any long term or short term side effects on infants? Can Prochlorperazine influence milk supply or can Prochlorperazine decrease milk supply in lactating mothers?

Prochlorperazine lactation summary

Prochlorperazine is unsafe in breastfeeding
  • DrLact safety Score for Prochlorperazine is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of Prochlorperazine may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that Prochlorperazine may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using Prochlorperazine .
  • It is recommended to evaluate the advantage of not breastfeeding while using Prochlorperazine Vs not using Prochlorperazine And continue breastfeeding.
  • While using Prochlorperazine Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Prochlorperazine usage in lactation

May be a cause of galactorhrea by stimulting release of prolactin. Not commercially available in Spain

Answer by DrLact: About Prochlorperazine usage in lactation

Based on minimal excretion of other phenothiazine derivatives, it appears that occasional short-term use of prochlorperazine for the treatment of nausea and vomiting poses little risk to the breastfed infant.

Prochlorperazine Possible Effects in Breastfeeding

Galactorrhea has been reported with prochlorperazine.[1] Hyperprolactinemia appears to be the cause of the galactorrhea.[2][3][4] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[5] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.