Question

I am a breastfeeding mother and i want to know if it is safe to use Fludrocortisone Acetate? Is Fludrocortisone Acetate safe for nursing mother and child? Does Fludrocortisone Acetate extracts into breast milk? Does Fludrocortisone Acetate has any long term or short term side effects on infants? Can Fludrocortisone Acetate influence milk supply or can Fludrocortisone Acetate decrease milk supply in lactating mothers?

Fludrocortisone Acetate lactation summary

Fludrocortisone Acetate usage has low risk in breastfeeding
  • DrLact safety Score for Fludrocortisone Acetate is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Fludrocortisone Acetate may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Fludrocortisone Acetate may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Fludrocortisone Acetate low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Fludrocortisone Acetate We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Fludrocortisone Acetate usage in lactation

Steroidal drug with glucocorticoid action and high activity as mineralocorticoid.Systemic administration: oral route. Topical administration: creams as dermatologic compounds and eye drops for ophthalmologic use.Indicated as replacement therapy in Adrenal Insufficiency (Addison’s Disease) and "salt-losing" Congenital Adrenal Hyperplasia. At latest update relevant published data were not found on excretion into breast milk.Other corticosteroids are know to be excreted into breastmilk in small amounts.Since the goal of treatment is to keep the mother within normal plasma hormone ranges, by monitoring adequately through analytical controls to make sure the mother is receiving a correct dose, it would neither interfere with breastfeeding nor would be harmful to the infant. Take as lowest effective dose as possible with follow-up the infant for hypo-adrenal signs. The small dose used along with a poor passage to plasma of most ophthalmologic and topical dermatologic preparations makes it very unlikely that a significant excretion into breastmilk would occur.Do not apply on the breast to prevent ingestion by the infant; otherwise, do it just after a meal and clean the nipple thoroughly with water before the next feed. Mineral-corticoid poisoning occurred in an infant after long-term application of a corticoid cream on the nipple (De Stefano 1983).
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