Question

I am a breastfeeding mother and i want to know if it is safe to use 9-Hydroxyrisperidone? Is 9-Hydroxyrisperidone safe for nursing mother and child? Does 9-Hydroxyrisperidone extracts into breast milk? Does 9-Hydroxyrisperidone has any long term or short term side effects on infants? Can 9-Hydroxyrisperidone influence milk supply or can 9-Hydroxyrisperidone decrease milk supply in lactating mothers?

9-Hydroxyrisperidone lactation summary

9-Hydroxyrisperidone is safe in breastfeeding
  • DrLact safety Score for 9-Hydroxyrisperidone is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of 9-Hydroxyrisperidone is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that 9-Hydroxyrisperidone does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of 9-Hydroxyrisperidone safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 9-Hydroxyrisperidone usage in lactation

Risperidone and its metabolite (9-Hydroxyrisperidone) are excreted into breast milk in non-significant amount. Untoward effect has not been observed on breastfed infants of treated mothers. Serum levels were very low or undetectable in these infants. May be a cause of galactorrhea. Thera are two types of 9-Hydroxyrisperidone: oral and intramuscular (Depo). Depo type (9-Hydroxyrisperidone Palmitate) requires intramuscular administration with a Time to Max of 13 days and a Half-time of 25 to 50 days. That would be a reason to use during breastfeeding a non-depot (oral) medication like Risperidone or any suggested alternative, as a safer choice.

Answer by DrLact: About 9-Hydroxyrisperidone usage in lactation

Although no data are available for the use of 9-Hydroxyrisperidone during breastfeeding, it is the active metabolite of risperidone. Risperidone data indicate that the concentrations of 9-Hydroxyrisperidone (9-hydroxyrisperidone) in breastmilk are low, and amounts ingested by the infant are small. Because there is no published experience with 9-Hydroxyrisperidone during breastfeeding and little long-term follow-up data, other agents may be preferred, especially while nursing a newborn or preterm infant. Because 9-Hydroxyrisperidone is available only as a sustained-release product, timing of nursing with respect to doses would not be useful.

9-Hydroxyrisperidone Side Effects in Breastfeeding

No published information on 9-Hydroxyrisperidone was found as of the revision date. However, limited data from the use of its parent drug, risperidone, during nursing indicate no short- or long-term adverse effects on the infant.[3][4][5]

9-Hydroxyrisperidone Possible Effects in Breastfeeding

9-Hydroxyrisperidone has caused elevated prolactin serum levels, gynecomastia, and galactorrhea in patients taking the drug.[6][7][8][9][10][11] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.