Is 9-Hydroxyrisperidone Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 9-Hydroxyrisperidone? Is 9-Hydroxyrisperidone safe for nursing mother and child? Does 9-Hydroxyrisperidone extracts into breast milk? Does 9-Hydroxyrisperidone has any long term or short term side effects on infants? Can 9-Hydroxyrisperidone influence milk supply or can 9-Hydroxyrisperidone decrease milk supply in lactating mothers?

Risperidone and its metabolite (9-Hydroxyrisperidone) are excreted into breast milk in non-significant amount. Untoward effect has not been observed on breastfed infants of treated mothers. Serum levels were very low or undetectable in these infants. May be a cause of galactorrhea. Thera are two types of 9-Hydroxyrisperidone: oral and intramuscular (Depo). Depo type (9-Hydroxyrisperidone Palmitate) requires intramuscular administration with a Time to Max of 13 days and a Half-time of 25 to 50 days. That would be a reason to use during breastfeeding a non-depot (oral) medication like Risperidone or any suggested alternative, as a safer choice.

Although no data are available for the use of 9-Hydroxyrisperidone during breastfeeding, it is the active metabolite of risperidone. Risperidone data indicate that the concentrations of 9-Hydroxyrisperidone (9-hydroxyrisperidone) in breastmilk are low, and amounts ingested by the infant are small. Because there is no published experience with 9-Hydroxyrisperidone during breastfeeding and little long-term follow-up data, other agents may be preferred, especially while nursing a newborn or preterm infant. Because 9-Hydroxyrisperidone is available only as a sustained-release product, timing of nursing with respect to doses would not be useful.

No published information on 9-Hydroxyrisperidone was found as of the revision date. However, limited data from the use of its parent drug, risperidone, during nursing indicate no short- or long-term adverse effects on the infant.[3][4][5]

9-Hydroxyrisperidone has caused elevated prolactin serum levels, gynecomastia, and galactorrhea in patients taking the drug.[6][7][8][9][10][11] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.