Is 9-OH-risperidone Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 9-OH-risperidone? Is 9-OH-risperidone safe for nursing mother and child? Does 9-OH-risperidone extracts into breast milk? Does 9-OH-risperidone has any long term or short term side effects on infants? Can 9-OH-risperidone influence milk supply or can 9-OH-risperidone decrease milk supply in lactating mothers?
9-OH-risperidone lactation summary
- DrLact safety Score for 9-OH-risperidone is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of 9-OH-risperidone is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that 9-OH-risperidone does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of 9-OH-risperidone safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 9-OH-risperidone usage in lactation
Risperidone and its metabolite (9-OH-risperidone) are excreted into breast milk in non-significant amount. Untoward effect has not been observed on breastfed infants of treated mothers. Serum levels were very low or undetectable in these infants. May be a cause of galactorrhea. Thera are two types of 9-OH-risperidone: oral and intramuscular (Depo). Depo type (9-OH-risperidone Palmitate) requires intramuscular administration with a Time to Max of 13 days and a Half-time of 25 to 50 days. That would be a reason to use during breastfeeding a non-depot (oral) medication like Risperidone or any suggested alternative, as a safer choice.
Answer by DrLact: About 9-OH-risperidone usage in lactation
Although no data are available for the use of 9-OH-risperidone during breastfeeding, it is the active metabolite of risperidone. Risperidone data indicate that the concentrations of 9-OH-risperidone (9-hydroxyrisperidone) in breastmilk are low, and amounts ingested by the infant are small. Because there is no published experience with 9-OH-risperidone during breastfeeding and little long-term follow-up data, other agents may be preferred, especially while nursing a newborn or preterm infant. Because 9-OH-risperidone is available only as a sustained-release product, timing of nursing with respect to doses would not be useful.
9-OH-risperidone Side Effects in Breastfeeding
No published information on 9-OH-risperidone was found as of the revision date. However, limited data from the use of its parent drug, risperidone, during nursing indicate no short- or long-term adverse effects on the infant.[3][4][5]
9-OH-risperidone Possible Effects in Breastfeeding
9-OH-risperidone has caused elevated prolactin serum levels, gynecomastia, and galactorrhea in patients taking the drug.[6][7][8][9][10][11] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs
Chlorpromazine(Low Risk)
Sulpiride(Safe)
Aripiprazole(Low Risk)
Ziprasidone(Unsafe)
Trifluoperazine(Safe)
Thiothixene(Unsafe)
Thioridazine(Unsafe)
Risperidone(Safe)
Quetiapine(Safe)
Pimozide(Unsafe)
Perphenazine(Safe)
Flupenthixol(Safe)
Olanzapine(Safe)
Zuclopenthixol(Safe)
Mesoridazine(Unsafe)
Loxapine(Unsafe)
Haloperidol(Safe)
Asenapine(Low Risk)
Fluphenazine(Low Risk)
Droperidol(Low Risk)
Clozapine(Low Risk)
Paliperidone(Safe)