Is 9-OH-risperidone Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 9-OH-risperidone? Is 9-OH-risperidone safe for nursing mother and child? Does 9-OH-risperidone extracts into breast milk? Does 9-OH-risperidone has any long term or short term side effects on infants? Can 9-OH-risperidone influence milk supply or can 9-OH-risperidone decrease milk supply in lactating mothers?
9-OH-risperidone lactation summary
- DrLact safety Score for 9-OH-risperidone is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of 9-OH-risperidone is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that 9-OH-risperidone does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of 9-OH-risperidone safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 9-OH-risperidone usage in lactation
Risperidone and its metabolite (9-OH-risperidone) are excreted into breast milk in non-significant amount. Untoward effect has not been observed on breastfed infants of treated mothers. Serum levels were very low or undetectable in these infants. May be a cause of galactorrhea. Thera are two types of 9-OH-risperidone: oral and intramuscular (Depo). Depo type (9-OH-risperidone Palmitate) requires intramuscular administration with a Time to Max of 13 days and a Half-time of 25 to 50 days. That would be a reason to use during breastfeeding a non-depot (oral) medication like Risperidone or any suggested alternative, as a safer choice.
Answer by DrLact: About 9-OH-risperidone usage in lactation
Although no data are available for the use of 9-OH-risperidone during breastfeeding, it is the active metabolite of risperidone. Risperidone data indicate that the concentrations of 9-OH-risperidone (9-hydroxyrisperidone) in breastmilk are low, and amounts ingested by the infant are small. Because there is no published experience with 9-OH-risperidone during breastfeeding and little long-term follow-up data, other agents may be preferred, especially while nursing a newborn or preterm infant. Because 9-OH-risperidone is available only as a sustained-release product, timing of nursing with respect to doses would not be useful.
9-OH-risperidone Side Effects in Breastfeeding
No published information on 9-OH-risperidone was found as of the revision date. However, limited data from the use of its parent drug, risperidone, during nursing indicate no short- or long-term adverse effects on the infant.[3][4][5]
9-OH-risperidone Possible Effects in Breastfeeding
9-OH-risperidone has caused elevated prolactin serum levels, gynecomastia, and galactorrhea in patients taking the drug.[6][7][8][9][10][11] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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