Is HSDB 8148 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use HSDB 8148? Is HSDB 8148 safe for nursing mother and child? Does HSDB 8148 extracts into breast milk? Does HSDB 8148 has any long term or short term side effects on infants? Can HSDB 8148 influence milk supply or can HSDB 8148 decrease milk supply in lactating mothers?
HSDB 8148 lactation summary
- DrLact safety Score for HSDB 8148 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of HSDB 8148 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that HSDB 8148 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of HSDB 8148 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About HSDB 8148 usage in lactation
Risperidone and its metabolite (HSDB 8148) are excreted into breast milk in non-significant amount. Untoward effect has not been observed on breastfed infants of treated mothers. Serum levels were very low or undetectable in these infants. May be a cause of galactorrhea. Thera are two types of HSDB 8148: oral and intramuscular (Depo). Depo type (HSDB 8148 Palmitate) requires intramuscular administration with a Time to Max of 13 days and a Half-time of 25 to 50 days. That would be a reason to use during breastfeeding a non-depot (oral) medication like Risperidone or any suggested alternative, as a safer choice.
Answer by DrLact: About HSDB 8148 usage in lactation
Although no data are available for the use of HSDB 8148 during breastfeeding, it is the active metabolite of risperidone. Risperidone data indicate that the concentrations of HSDB 8148 (9-hydroxyrisperidone) in breastmilk are low, and amounts ingested by the infant are small. Because there is no published experience with HSDB 8148 during breastfeeding and little long-term follow-up data, other agents may be preferred, especially while nursing a newborn or preterm infant. Because HSDB 8148 is available only as a sustained-release product, timing of nursing with respect to doses would not be useful.
HSDB 8148 Side Effects in Breastfeeding
No published information on HSDB 8148 was found as of the revision date. However, limited data from the use of its parent drug, risperidone, during nursing indicate no short- or long-term adverse effects on the infant.[3][4][5]
HSDB 8148 Possible Effects in Breastfeeding
HSDB 8148 has caused elevated prolactin serum levels, gynecomastia, and galactorrhea in patients taking the drug.[6][7][8][9][10][11] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs
Thioridazine(Unsafe)
Risperidone(Safe)
Quetiapine(Safe)
Pimozide(Unsafe)
Perphenazine(Safe)
Olanzapine(Safe)
Flupenthixol(Safe)
Zuclopenthixol(Safe)
Mesoridazine(Unsafe)
Loxapine(Unsafe)
Asenapine(Low Risk)
Haloperidol(Safe)
Droperidol(Low Risk)
Fluphenazine(Low Risk)
Paliperidone(Safe)
Clozapine(Low Risk)
Sulpiride(Safe)
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Ziprasidone(Unsafe)
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Thiothixene(Unsafe)