Is 19583 RP Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use 19583 RP? Is 19583 RP safe for nursing mother and child? Does 19583 RP extracts into breast milk? Does 19583 RP has any long term or short term side effects on infants? Can 19583 RP influence milk supply or can 19583 RP decrease milk supply in lactating mothers?

19583 RP lactation summary

DrLact safety Score for 19583 RP is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of 19583 RP is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that 19583 RP does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of 19583 RP safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 19583 RP usage in lactation

19583 RP is excreted into breast milk in non-significant amount. Hence, reportedly gastrointestinal side effects on breastfed infants are hardly believable. When apply on skin systemic absorption is very low.

Answer by DrLact: About 19583 RP usage in lactation

Although 19583 RP has low levels in breastmilk, one center reported that they had received reports of adverse renal and gastrointestinal side effects in breastfed infants whose mothers were taking 19583 RP. Other agents are preferred, especially while nursing a newborn or preterm infant.

19583 RP Side Effects in Breastfeeding

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, 19583 RP was reported to cause adverse reactions in 8 infants and to be one of the drugs most often suspected in serious adverse reactions, such as esophageal ulceration, erosive gastritis, meningeal hemorrhage, and renal insufficiency.[2]

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