Is Ketoprofene [INN-French] Safe in Breastfeeding

Question

I am a breastfeeding mother and i want to know if it is safe to use Ketoprofene [INN-French]? Is Ketoprofene [INN-French] safe for nursing mother and child? Does Ketoprofene [INN-French] extracts into breast milk? Does Ketoprofene [INN-French] has any long term or short term side effects on infants? Can Ketoprofene [INN-French] influence milk supply or can Ketoprofene [INN-French] decrease milk supply in lactating mothers?

Ketoprofene [INN-French] lactation summary

Ketoprofene [INN-French] is safe in breastfeeding

DrLact safety Score for Ketoprofene [INN-French] is 1 out of 8 which is considered Safe as per our analyses.
A safety Score of 1 indicates that usage of Ketoprofene [INN-French] is mostly safe during lactation for breastfed baby.
Our study of different scientific research also indicates that Ketoprofene [INN-French] does not cause any serious side effects in breastfeeding mothers.
Most of scientific studies and research papers declaring usage of Ketoprofene [INN-French] safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Ketoprofene [INN-French] usage in lactation

Ketoprofene [INN-French] is excreted into breast milk in non-significant amount. Hence, reportedly gastrointestinal side effects on breastfed infants are hardly believable. When apply on skin systemic absorption is very low.

Answer by DrLact: About Ketoprofene [INN-French] usage in lactation

Although Ketoprofene [INN-French] has low levels in breastmilk, one center reported that they had received reports of adverse renal and gastrointestinal side effects in breastfed infants whose mothers were taking Ketoprofene [INN-French]. Other agents are preferred, especially while nursing a newborn or preterm infant.

Ketoprofene [INN-French] Side Effects in Breastfeeding

All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, Ketoprofene [INN-French] was reported to cause adverse reactions in 8 infants and to be one of the drugs most often suspected in serious adverse reactions, such as esophageal ulceration, erosive gastritis, meningeal hemorrhage, and renal insufficiency.[2]

Alternate Drugs

Salsalate

Ibuprofen(Safe)

Piroxicam(Safe)

Dipyrone(Low Risk)

Flurbiprofen(Safe)

Naproxen(Low Risk)

Ketoprofen(Safe)

Fenoprofen(Safe)

Nabumetone(Low Risk)

Etodolac(Low Risk)

Meloxicam(Low Risk)

Aspirin(Low Risk)

Diflunisal(Low Risk)

Mefenamic Acid(Safe)

Oxaprozin(Low Risk)

Diclofenac(Safe)

Nepafenac

Meclofenamate(Low Risk)

Valdecoxib

Celecoxib(Safe)

Bromfenac

Ketorolac(Safe)

Tolmetin(Safe)

Choline Magnesium Salicylate

Indomethacin(Safe)

Sulindac(Low Risk)