Is RU 4733 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use RU 4733? Is RU 4733 safe for nursing mother and child? Does RU 4733 extracts into breast milk? Does RU 4733 has any long term or short term side effects on infants? Can RU 4733 influence milk supply or can RU 4733 decrease milk supply in lactating mothers?
RU 4733 lactation summary
- DrLact safety Score for RU 4733 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of RU 4733 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that RU 4733 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of RU 4733 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About RU 4733 usage in lactation
RU 4733 is excreted into breast milk in non-significant amount. Hence, reportedly gastrointestinal side effects on breastfed infants are hardly believable. When apply on skin systemic absorption is very low.
Answer by DrLact: About RU 4733 usage in lactation
Although RU 4733 has low levels in breastmilk, one center reported that they had received reports of adverse renal and gastrointestinal side effects in breastfed infants whose mothers were taking RU 4733. Other agents are preferred, especially while nursing a newborn or preterm infant.
RU 4733 Side Effects in Breastfeeding
All adverse reactions in breastfed infants reported in France between January 1985 and June 2011 were compiled by a French pharmacovigilance center. Of 174 reports, RU 4733 was reported to cause adverse reactions in 8 infants and to be one of the drugs most often suspected in serious adverse reactions, such as esophageal ulceration, erosive gastritis, meningeal hemorrhage, and renal insufficiency.[2]
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