Is Goserelin Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Goserelin? Is Goserelin safe for nursing mother and child? Does Goserelin extracts into breast milk? Does Goserelin has any long term or short term side effects on infants? Can Goserelin influence milk supply or can Goserelin decrease milk supply in lactating mothers?
Goserelin lactation summary
- DrLact safety Score for Goserelin is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Goserelin may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Goserelin may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Goserelin low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Goserelin We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Goserelin usage in lactation
It is a GNRH analogue that works like an inhibitor of Hypophysis Gonadotropin (LH & FSH) secretion. A continue use produces a decrease of Estradiol level to those seen during the post-menopause period. A decrease of breast milk production is possible. When used for the treatment of infertility, the anovulatory effect of breastfeeding should be taken into account, if it is done with a frequent on-demand feeding. At latest update, no relevant published data concerning excretion into breast milk were found. Its high molecular weight makes excretion into breast milk be unlikely. Also, a low oral bioavailability renders the absorption of this agent into the infant's plasma be nil or minimal.
Alternate Drugs for Antineoplastics: Hormonal, analogues and antagonists agents. ATC L02
Tamoxifen(Dangerous)
Letrozole(Dangerous)
Buserelin(Low Risk)
Leuprorelin(Low Risk)
Tamoxifen Citrate(Dangerous)
Triptorelin(Low Risk)