Is HSDB 8252 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use HSDB 8252? Is HSDB 8252 safe for nursing mother and child? Does HSDB 8252 extracts into breast milk? Does HSDB 8252 has any long term or short term side effects on infants? Can HSDB 8252 influence milk supply or can HSDB 8252 decrease milk supply in lactating mothers?

• DrLact safety Score for HSDB 8252 is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of HSDB 8252 may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that HSDB 8252 may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using HSDB 8252 .
• It is recommended to evaluate the advantage of not breastfeeding while using HSDB 8252 Vs not using HSDB 8252 And continue breastfeeding.
• While using HSDB 8252 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Non-ergotamine and D2 /D3 Dopamine agonist drug.Indicated for Parkinson's disease and Restless Legs Syndrome (Evening dose). At latest update no published data on excretion into breast milk were found.Pharmacokinetic data do not allow easily predict the possibility of excretion into breastmilk, since a low protein-binding capacity would not prevent it, however, a large distribution volume would make it unlikely.Its low oral bioavailability which decreases even more when taken with meals, suggests that plasma concentration would reach a very low level in the infant, except during the neonatal period and in case of prematurity in which intestinal absorption may be increased.Side effects are neither frequent nor severe. Prolactin levels may be lowered with decreased production of breastmilk during the first weeks after birth.Gut absorption may be increased with higher plasma levels if taken together with Ciprofloxacin (Kaye 2000). Whenever it is used while breastfeeding, it would be wise avoiding it during the first 15 to 20 days and assess milk production and onset of nausea, drowsiness or irritability in infants.By waiting six hours after medication, excretion into breastmilk would possibly be lowered.

No information is available on the use of HSDB 8252 during breastfeeding, but it suppresses serum prolactin and may interfere with breastfeeding. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Relevant published information in nursing mothers was not found as of the revision date. HSDB 8252 lowers serum prolactin.[1] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.