Is 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide? Is 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide safe for nursing mother and child? Does 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide extracts into breast milk? Does 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide has any long term or short term side effects on infants? Can 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide influence milk supply or can 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide decrease milk supply in lactating mothers?
1,2-Benzisothiazol-3(2H)-one 1,1-dioxide lactation summary
- DrLact safety Score for 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide usage in lactation
Calcium 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide and other related salts, sodium and potassium, are potent sweeteners. They are excreted into breast milk in very small amount, which makes the infant may receive at most a dose of 0.26 mg / kg / day, which is well below the maximum recommended dose suggested by the FDA (5 mg / kg / day). There is controversy on the genotoxic and carcinogenic effects of 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, since though when administered to animals it does appear genotoxicity at large doses, no evidence of its occurrence in human populations with regular consumption of 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide has been found. Moderate intake is compatible with breastfeeding.
Answer by DrLact: About 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide usage in lactation
Because of the low levels of 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide in breastmilk, amounts ingested by the infant after typical maternal intake are small and would not be expected to cause any adverse effects in breastfed infants. However, some authors suggest that women may wish to limit the consumption of nonnutritive sweeteners while breastfeeding because their effect on the nursing infants are unknown.[1][2]