Is UK-427,857 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use UK-427,857? Is UK-427,857 safe for nursing mother and child? Does UK-427,857 extracts into breast milk? Does UK-427,857 has any long term or short term side effects on infants? Can UK-427,857 influence milk supply or can UK-427,857 decrease milk supply in lactating mothers?

In the United States and other developed countries, HIV-infected mothers should generally not breastfeed their infants. No published information is available on the use of UK-427,857 during breastfeeding. In countries in which no acceptable, feasible, sustainable and safe replacement feeding is available, World Health Organization guidelines recommend that all women with an HIV infection who are pregnant or breastfeeding should be maintained on antiretroviral therapy for at least the duration of risk for mother-to-child transmission.Mothers should exclusively breastfeed their infants for the first 6 months of life; breastfeeding with complementary feeding should continue through at least 12 months of life up to 24 months of life.[1] The first choice regimen for nursing mothers is tenofovir, efavirenz and either lamivudine or emtricitabine. If these drugs are unavailable, alternative regimens include: 1) zidovudine, lamivudine and efavirenz; 2) zidovudine, lamivudine and nevirapine; or 3) tenofovir, nevirapine and either lamivudine or emtricitabine. Exclusively breastfed infants should also receive 6 weeks of prophylaxis with nevirapine.[2][3]

Some case reports have suggested that antiretrovirals, including lamivudine, might cause hyperprolactinemia and galactorrhea in some patients,[14] although this has been disputed.[15] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.