Is Cetrorelix Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Cetrorelix? Is Cetrorelix safe for nursing mother and child? Does Cetrorelix extracts into breast milk? Does Cetrorelix has any long term or short term side effects on infants? Can Cetrorelix influence milk supply or can Cetrorelix decrease milk supply in lactating mothers?
Cetrorelix lactation summary
- DrLact safety Score for Cetrorelix is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Cetrorelix may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Cetrorelix may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Cetrorelix low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Cetrorelix We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Cetrorelix usage in lactation
Is a decapeptide with a sequence derived from gonadotropin releasing hormones (GnRH or LHRH), and is a LHRH-antagonist. It is not secreted into breast milk because of a large molecular weight. It is readily destroyed by the child’s stomach acid milieu. Keep in mind that there is a known anovulatory effect of lactation that is related to sucking frequency.
Alternate Drugs for Hypothalamic Hormone
Octreotide(Safe)
Melatonin(Safe)
Gonadorelin(Low Risk)
Nafarelin(Low Risk)
Protirelin(Safe)
Somatostatin(Unsafe)
Ganirelix Acetate(Low Risk)
Trh(Safe)