Question

I am a breastfeeding mother and i want to know if it is safe to use Ulipristal Acetate (Myomas)? Is Ulipristal Acetate (Myomas) safe for nursing mother and child? Does Ulipristal Acetate (Myomas) extracts into breast milk? Does Ulipristal Acetate (Myomas) has any long term or short term side effects on infants? Can Ulipristal Acetate (Myomas) influence milk supply or can Ulipristal Acetate (Myomas) decrease milk supply in lactating mothers?

Ulipristal Acetate (Myomas) lactation summary

Ulipristal Acetate (Myomas) usage has low risk in breastfeeding
  • DrLact safety Score for Ulipristal Acetate (Myomas) is 3 out of 8 which is considered Low Risk as per our analyses.
  • A safety Score of 3 indicates that usage of Ulipristal Acetate (Myomas) may cause some minor side effects in breastfed baby.
  • Our study of different scientific research indicates that Ulipristal Acetate (Myomas) may cause moderate to no side effects in lactating mother.
  • Most of scientific studies and research papers declaring usage of Ulipristal Acetate (Myomas) low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • While using Ulipristal Acetate (Myomas) We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Ulipristal Acetate (Myomas) usage in lactation

Selective modulator of progesterone receptors with slightly antagonistic effect on it.It is used on the treatment of uterine fibroids (Donnez 2012, Vázquez 2013) A high plasma protein-binding capacity explains its small passage (0.02 mg / L) into breastmilk observed at the first day (HRA Pharma 2015: 8.3). As an emergency contraceptive it is a medication of limited and occasional use. World Health Organization considers it compatible with breastfeeding on such cases. (WHO 2015). See specific info on "Ulipristal acetate (contraceptive)". On the treatment of fibroids, the issue of a possible increased risk is posed on long lasting treatments (one daily intake on cycles of 3 months each at a maximum of 4 cycles with a two-months resting period between cycles). Theoretically, the relative daily dose ingested by the infant would reach 1%, that is, on an each complete cycle (90 days) the infant would not even have been able to ingest the dose (weight-based) corresponding to one-day treatment.There are no published data on this medication related to breastfeeding, hence, a known safer alternative should be evaluated by following the best health caregiver knowledge.

Alternate Drugs for Sex hormone antagonists and modulators of the genital system. ATC G03H & G03X

Mifepristone(Low Risk)
Cyproterone Acetate(Unsafe)
Raloxifene Hydrochloride(Unsafe)
Toremifene(Dangerous)
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