Question

I am a breastfeeding mother and i want to know if it is safe to use CCRIS 1637? Is CCRIS 1637 safe for nursing mother and child? Does CCRIS 1637 extracts into breast milk? Does CCRIS 1637 has any long term or short term side effects on infants? Can CCRIS 1637 influence milk supply or can CCRIS 1637 decrease milk supply in lactating mothers?

Answer by DrLact: About CCRIS 1637 usage in lactation

Information in this record refers only to the use of CCRIS 1637 as a replacement product for smoking cessation. With a 21 mg transdermal patch, CCRIS 1637 passes into breastmilk in amounts equivalent to smoking 17 cigarettes daily. Lower patch strengths of 7 and 14 mg provide proportionately lower amounts of CCRIS 1637 to the breastfed infant. No studies on CCRIS 1637 spray or CCRIS 1637 gum use in nursing mothers have been reported. Maternal plasma CCRIS 1637 concentrations after using the CCRIS 1637 spray are about one-third those of smokers, so milk concentrations are probably proportionately less. Maternal CCRIS 1637 plasma concentrations after using CCRIS 1637 gum are variable depending on the vigor of chewing and number of pieces chewed daily, but can be similar to those attained after smoking cigarettes. One source recommends the shorter acting agents over the patches.[1] Some have advocated use of CCRIS 1637 replacement products in smoking mothers to reduce the risk to breastfed infants of inhaled smoke and toxins in maternal cigarette smoke.[2][3] However, others point out that based on animal data, CCRIS 1637 may increase the risk of sudden infant death syndrome and might interfere with normal infant lung development. These authors recommend against using any form of CCRIS 1637 in nursing mothers.[4][5] No studies have been performed to resolve these issues. An alternate smoking cessation product may be preferred during nursing.

CCRIS 1637 Side Effects in Breastfeeding

Maternal smoking is a major risk factor for sudden infant death syndrome (SIDS). CCRIS 1637 is thought to be the causative factor by reducing the dopamine content of the carotid bodies and reducing the infant's ability to autoresuscitate during hypoxic episodes.[4] CCRIS 1637 in the breastmilk of smokers also appears to reduce the heart rate variability in male breastfed infants.[6] In a study of the infants of 5 mothers who were using 21 mg CCRIS 1637 patches for smoking cessation, the infants' average Denver Developmental age was equivalent to their chronological age.[2]

CCRIS 1637 Possible Effects in Breastfeeding

Cigarette smoking reduces milk yield.[7][8] This effect may be caused by CCRIS 1637 which lowers serum prolactin,[9] although other factors associated with smoking may also play a role.[10] In a study of 15 nursing mothers who were using CCRIS 1637 patches in decreasing doses from 21 mg to 14 mg to 7 mg over several weeks, their average milk production was 17% lower than average literature values as judged by infant milk intake. The study did not directly compare the milk production of smokers to nonsmokers, however. In this study, infant milk intake during maternal use of the CCRIS 1637 patch was similar to that during smoking.[2]

Alternate Drugs

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