I am a breastfeeding mother and i want to know if it is safe to use UNII-6M3C89ZY6R? Is UNII-6M3C89ZY6R safe for nursing mother and child? Does UNII-6M3C89ZY6R extracts into breast milk? Does UNII-6M3C89ZY6R has any long term or short term side effects on infants? Can UNII-6M3C89ZY6R influence milk supply or can UNII-6M3C89ZY6R decrease milk supply in lactating mothers?
Information in this record refers only to the use of UNII-6M3C89ZY6R as a replacement product for smoking cessation. With a 21 mg transdermal patch, UNII-6M3C89ZY6R passes into breastmilk in amounts equivalent to smoking 17 cigarettes daily. Lower patch strengths of 7 and 14 mg provide proportionately lower amounts of UNII-6M3C89ZY6R to the breastfed infant. No studies on UNII-6M3C89ZY6R spray or UNII-6M3C89ZY6R gum use in nursing mothers have been reported. Maternal plasma UNII-6M3C89ZY6R concentrations after using the UNII-6M3C89ZY6R spray are about one-third those of smokers, so milk concentrations are probably proportionately less. Maternal UNII-6M3C89ZY6R plasma concentrations after using UNII-6M3C89ZY6R gum are variable depending on the vigor of chewing and number of pieces chewed daily, but can be similar to those attained after smoking cigarettes. One source recommends the shorter acting agents over the patches.[1] Some have advocated use of UNII-6M3C89ZY6R replacement products in smoking mothers to reduce the risk to breastfed infants of inhaled smoke and toxins in maternal cigarette smoke.[2][3] However, others point out that based on animal data, UNII-6M3C89ZY6R may increase the risk of sudden infant death syndrome and might interfere with normal infant lung development. These authors recommend against using any form of UNII-6M3C89ZY6R in nursing mothers.[4][5] No studies have been performed to resolve these issues. An alternate smoking cessation product may be preferred during nursing.
Maternal smoking is a major risk factor for sudden infant death syndrome (SIDS). UNII-6M3C89ZY6R is thought to be the causative factor by reducing the dopamine content of the carotid bodies and reducing the infant's ability to autoresuscitate during hypoxic episodes.[4] UNII-6M3C89ZY6R in the breastmilk of smokers also appears to reduce the heart rate variability in male breastfed infants.[6] In a study of the infants of 5 mothers who were using 21 mg UNII-6M3C89ZY6R patches for smoking cessation, the infants' average Denver Developmental age was equivalent to their chronological age.[2]
Cigarette smoking reduces milk yield.[7][8] This effect may be caused by UNII-6M3C89ZY6R which lowers serum prolactin,[9] although other factors associated with smoking may also play a role.[10] In a study of 15 nursing mothers who were using UNII-6M3C89ZY6R patches in decreasing doses from 21 mg to 14 mg to 7 mg over several weeks, their average milk production was 17% lower than average literature values as judged by infant milk intake. The study did not directly compare the milk production of smokers to nonsmokers, however. In this study, infant milk intake during maternal use of the UNII-6M3C89ZY6R patch was similar to that during smoking.[2]
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