Is Diaphenylsulphone Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Diaphenylsulphone? Is Diaphenylsulphone safe for nursing mother and child? Does Diaphenylsulphone extracts into breast milk? Does Diaphenylsulphone has any long term or short term side effects on infants? Can Diaphenylsulphone influence milk supply or can Diaphenylsulphone decrease milk supply in lactating mothers?

One case of hemolytic anemia has been described. Check-up for development of jaundice in the infant. Avoid its use in patients affected of G-6-PD deficiency. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Diaphenylsulphone can be used during breastfeeding; however, hemolytic anemia might occur, especially in newborn infants and in those with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The time of greatest risk for hemolysis in fullterm newborns without G6PD deficiency might be as short as 8 days after birth.[1] One source states that use of Diaphenylsulphone in the treatment of leprosy is advantageous because it kills the organisms in breastmilk.[2] Monitor the infant for signs of hemolysis, especially in newborn or premature breastfed infants. Topical Diaphenylsulphone gel used to treat acne has not been studied during breastfeeding. According to the manufacturer, topical Diaphenylsulphone gel results in a blood level of 1% that of a 100 mg oral dose. It is unlikely that the topical gel would affect the breastfed infant, but the manufacturer states that it should not be used during nursing. Until more data are available, an alternative topical agent might be preferred.

A case of mild hemolytic anemia occurred in a 41-day-old breastfed infant whose mother was taking Diaphenylsulphone 50 mg daily. The hemolysis was probably caused by Diaphenylsulphone in milk.[3] A woman with leprosy took Diaphenylsulphone, clofazimine and rifampin during pregnancy and breastfeeding. Her infant developed skin discoloration attributed to clofazimine which reversed 3 months after cessation of breastfeeding.[5]