Is Tigecycline Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Tigecycline? Is Tigecycline safe for nursing mother and child? Does Tigecycline extracts into breast milk? Does Tigecycline has any long term or short term side effects on infants? Can Tigecycline influence milk supply or can Tigecycline decrease milk supply in lactating mothers?
Tigecycline lactation summary
- DrLact safety Score for Tigecycline is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Tigecycline may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Tigecycline may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Tigecycline low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Tigecycline We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Tigecycline usage in lactation
On latest update no relevant data related to breastfeeding were found. Pharmacokinetic data (wide distribution volume, moderately high molecular weight and high protein binding) suggest that excretion into breast milk would not be significant. Even more, low oral bioavailability makes absorption from ingested breast milk into infant’s blood be nil or scanty. However, in premature infants and neonates in early postpartum, blood levels are likely higher due to increased gut absorption. Nonetheless, a safer alternative with other known antibiotic is preferred until more information is available.
Alternate Drugs for Tetracycline antibacterials. ATC J01A
Demeclocycline(Low Risk)
Doxycycline(Low Risk)
Tetracycline(Safe)
Chlortetracycline(Low Risk)
Metacycline-Hcl(Unsafe)
Minocycline-Hcl(Low Risk)
Novobiocin(Unsafe)
Streptonivicin(Unsafe)
Declomycin(Low Risk)