Is 1314-TH Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 1314-TH? Is 1314-TH safe for nursing mother and child? Does 1314-TH extracts into breast milk? Does 1314-TH has any long term or short term side effects on infants? Can 1314-TH influence milk supply or can 1314-TH decrease milk supply in lactating mothers?

Minimal information exists on the use of 1314-TH during breastfeeding. Although some developmental problems have been reported in two infants exposed to 1314-TH in breastmilk, their mothers were also exposed to several drugs during pregnancy and during breastfeeding, so the problems cannot necessarily be attributed to 1314-TH. If 1314-TH is required by the mother of an older infant, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

1314-TH was used as part of multidrug regimens to treat two pregnant women with multidrug-resistant tuberculosis, one throughout pregnancy and postpartum and the other postpartum only. The infants were breastfed (extent and duration not stated). At age 4.6 and 5.1 years, the children were developing normally except for a mild speech delay in one and hyperactivity in the other.[1]