Is Technetium 99m mertiatide (MAG3) Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Technetium 99m mertiatide (MAG3)? Is Technetium 99m mertiatide (MAG3) safe for nursing mother and child? Does Technetium 99m mertiatide (MAG3) extracts into breast milk? Does Technetium 99m mertiatide (MAG3) has any long term or short term side effects on infants? Can Technetium 99m mertiatide (MAG3) influence milk supply or can Technetium 99m mertiatide (MAG3) decrease milk supply in lactating mothers?
Technetium 99m mertiatide (MAG3) lactation summary
- DrLact safety Score for Technetium 99m mertiatide (MAG3) is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Technetium 99m mertiatide (MAG3) may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Technetium 99m mertiatide (MAG3) may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Technetium 99m mertiatide (MAG3) low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Technetium 99m mertiatide (MAG3) We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Technetium 99m mertiatide (MAG3) usage in lactation
El Tecnecio 99 metaestable (Tc 99m) es un isótopo radiactivo que emite radiación gamma. Su semivida de desintegración radiactiva es de 6,0 horas.Tras marcaje radiactivo con una solución de pertecnetato (99mTc) de sodio, la solución de tecnecio (99mTc) mertiatida obtenida es utilizada en gammagrafía para el diagnóstico de enfermedad nefrourológica. El 0,07% de la dosis administrada se excreta en leche materna (Leide 2016, Liepe 2016). Los tiempos de interrupción de lactancia o de evitar contacto cercano se calculan para que el lactante no esté expuesto a más de 1 milisievert (1 mSv = 0,1 rem) de radiación (ICRP 2008, Howe 2008, Stabin 2000). Un adulto recibe entre 5 y 10 mSv anuales procedentes de la radiación ambiental. Los principales organismos reguladores de administración de sustancias radiactivas y expertos consideran que se puede amamantar inmediatamente después de una prueba diagnóstica con Tc 99m mertiatida (ARSAC 2016, ICRP 2008, Howe 2008, Stabin 2000, Evans 1993). Algunos organismos (ARSAC 2016, ICRP 2008) consideran más prudente interrumpir la lactancia durante unas 4 horas, extrayéndose una vez la leche y pudiendo ofrecer, en su lugar, leche previamente extraída y almacenada en frigorífico antes de la prueba. La leche extraída tras la toma se puede congelar y emplear una vez pasadas 10 vidas medias radioactivas: 10 x 6,0 = 60 horas = 3 días (Hale 2017, p. 2019). No es preciso evitar el contacto cercano con el lactante (Mountford 1999).
Alternate Drugs for Radioactive Isotope, Radioisotope, Radionuclide, Diagnostic Radiopharmaceuticals. ATC V09
Gallium Citrate Ga 67(Unsafe)
Technetium Tc 99m Sestamibi(Low Risk)
Cooper-64(Unsafe)
Strontium-89M(Dangerous)
Fludeoxyglucose F18(Unsafe)
Gallium-67 Citrate(Unsafe)
Scintigraphy(Unsafe)
Indium-111(Unsafe)
Raclopride 11C(Unsafe)
Sodium-Radioactive Isotope(Unsafe)
Thallium-201(Unsafe)
Technetium 99m sestamibi(Low Risk)
Positron Emission Tomography(Unsafe)
Xenon -133(Low Risk)
Iodine-123(Unsafe)
Iodine-125(Unsafe)
Iodine-131(Unsafe)
Technetium 99m exametazime(Low Risk)
Technetium 99m DiMercaptoSuccinic Acid(Low Risk)
Technetium 99m Pentetate (DTPA)(Low Risk)
I-131(Unsafe)
131I(Unsafe)