Is MK 217 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use MK 217? Is MK 217 safe for nursing mother and child? Does MK 217 extracts into breast milk? Does MK 217 has any long term or short term side effects on infants? Can MK 217 influence milk supply or can MK 217 decrease milk supply in lactating mothers?
MK 217 lactation summary
- DrLact safety Score for MK 217 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of MK 217 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that MK 217 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of MK 217 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using MK 217 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About MK 217 usage in lactation
It is composed by bisphosphonates. Most bisphosphonates are acidic compounds that achieve low plasma concentration. Both features make it unlikely excretion into the milk in clinically significant amount. MK 217 has shown very low plasma concentrations (<5 ng / ml). Intestinal absorption of bisphosphonates is very low even during fasting and is considered negligible in the presence of milk due to formation with the calcium of non absorbable compounds. A latest update no published data were found on excretion in the breast milk. Until more data about this drug regarding breastfeeding is available, safer known alternatives (e.g. pamidronate) should be of choice, especially in the neonatal period and in case of prematurity.
Answer by DrLact: About MK 217 usage in lactation
Limited evidence indicates that breastfeeding after cessation of long-term bisphosphonate treatment appears to have no adverse effects on the infant. Because no information is available on the use of MK 217 during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of MK 217 by a breastfed infant is unlikely. If the mother receives a bisphosphonate during pregnancy or nursing, some experts recommend monitoring the infant's serum calcium during the first 2 months postpartum.[1]
MK 217 Side Effects in Breastfeeding
Because MK 217 can persist in the body for years after long-term administration, the following cases may be relevant. A woman received MK 217 for 6 months, then pamidronate every 4 months for 1 year prior to conception. Her infant was breastfed (extent not stated) for 3 months. The infant had mild hypocalcemia at 2 months of age, but a normal calcium level and normal long bone development at 5 months of age.[2]
Alternate Drugs
Ibandronate(Low Risk)
Alendronate(Low Risk)
Risedronate(Low Risk)
Ibandronate(Low Risk)
Calcitriol(Safe)
Alendronate(Low Risk)
Risedronate(Low Risk)
Ibandronate(Low Risk)
Alendronate(Low Risk)
Risedronate(Low Risk)