Is Acide alendronique Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Acide alendronique? Is Acide alendronique safe for nursing mother and child? Does Acide alendronique extracts into breast milk? Does Acide alendronique has any long term or short term side effects on infants? Can Acide alendronique influence milk supply or can Acide alendronique decrease milk supply in lactating mothers?
Acide alendronique lactation summary
- DrLact safety Score for Acide alendronique is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Acide alendronique may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Acide alendronique may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Acide alendronique low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Acide alendronique We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Acide alendronique usage in lactation
It is composed by bisphosphonates. Most bisphosphonates are acidic compounds that achieve low plasma concentration. Both features make it unlikely excretion into the milk in clinically significant amount. Acide alendronique has shown very low plasma concentrations (<5 ng / ml). Intestinal absorption of bisphosphonates is very low even during fasting and is considered negligible in the presence of milk due to formation with the calcium of non absorbable compounds. A latest update no published data were found on excretion in the breast milk. Until more data about this drug regarding breastfeeding is available, safer known alternatives (e.g. pamidronate) should be of choice, especially in the neonatal period and in case of prematurity.
Answer by DrLact: About Acide alendronique usage in lactation
Limited evidence indicates that breastfeeding after cessation of long-term bisphosphonate treatment appears to have no adverse effects on the infant. Because no information is available on the use of Acide alendronique during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of Acide alendronique by a breastfed infant is unlikely. If the mother receives a bisphosphonate during pregnancy or nursing, some experts recommend monitoring the infant's serum calcium during the first 2 months postpartum.[1]
Acide alendronique Side Effects in Breastfeeding
Because Acide alendronique can persist in the body for years after long-term administration, the following cases may be relevant. A woman received Acide alendronique for 6 months, then pamidronate every 4 months for 1 year prior to conception. Her infant was breastfed (extent not stated) for 3 months. The infant had mild hypocalcemia at 2 months of age, but a normal calcium level and normal long bone development at 5 months of age.[2]
Alternate Drugs
Risedronate(Low Risk)
Ibandronate(Low Risk)
Alendronate(Low Risk)
Risedronate(Low Risk)
Ibandronate(Low Risk)
Calcitriol(Safe)
Alendronate(Low Risk)
Risedronate(Low Risk)
Ibandronate(Low Risk)
Alendronate(Low Risk)