Is UNII-9451Z89515 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use UNII-9451Z89515? Is UNII-9451Z89515 safe for nursing mother and child? Does UNII-9451Z89515 extracts into breast milk? Does UNII-9451Z89515 has any long term or short term side effects on infants? Can UNII-9451Z89515 influence milk supply or can UNII-9451Z89515 decrease milk supply in lactating mothers?
UNII-9451Z89515 lactation summary
- DrLact safety Score for UNII-9451Z89515 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of UNII-9451Z89515 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that UNII-9451Z89515 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of UNII-9451Z89515 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using UNII-9451Z89515 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About UNII-9451Z89515 usage in lactation
It is a carbonic anhydrase (CA) inhibitor sulphonamide drug which is used as 1% drops for topical treatment to lower intraocular pressure or glaucoma. EMEA and FDA have informed of very low serum levels found to be bound to CA red blood cells even after oral ingestion. For this reason and because it is usually used as a topical treatment its presence in mother’s milk is unlikely. Like most ophthalmologic compounds for topical use, a low dose and poor absorption make it compatible with breastfeeding. Pressing conjunctiva sack for a couple of minutes to lessen systemic absorption.
Answer by DrLact: About UNII-9451Z89515 usage in lactation
Because no information is available on the use of UNII-9451Z89515 during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
Alternate Drugs
Acetazolamide(Safe)
Timolol(Safe)
Travoprost(Safe)
Levobunolol(Low Risk)
Pilocarpine(Unsafe)
Latanoprost(Safe)
Epinephrine(Safe)
Brinzolamide(Low Risk)
Brimonidine(Safe)
Bimatoprost(Safe)
Carteolol(Unsafe)
Phenylephrine(Low Risk)
Brinzolamide(Low Risk)
Acetazolamide(Safe)